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The importance of early treatment with tranexamic acid in bleeding trauma patients: an exploratory analysis of the CRASH-2 randomised controlled trial.
CRASH-2 collaborators; Roberts I, Shakur H, Afolabi A, Brohi K, Coats T, Dewan Y, Gando S, Guyatt G, Hunt BJ, Morales C, Perel P, Prieto-Merino D, Woolley T. CRASH-2 collaborators, et al. Lancet. 2011 Mar 26;377(9771):1096-101, 1101.e1-2. doi: 10.1016/S0140-6736(11)60278-X. Lancet. 2011. PMID: 21439633 Clinical Trial.
CRASH-2 (Clinical Randomisation of an Antifibrinolytic in Significant Haemorrhage) intracranial bleeding study: the effect of tranexamic acid in traumatic brain injury--a nested randomised, placebo-controlled trial.
Perel P, Al-Shahi Salman R, Kawahara T, Morris Z, Prieto-Merino D, Roberts I, Sandercock P, Shakur H, Wardlaw J. Perel P, et al. Health Technol Assess. 2012;16(13):iii-xii, 1-54. doi: 10.3310/hta16130. Health Technol Assess. 2012. PMID: 22417901 Free article. Clinical Trial.
The CRASH-2 trial: a randomised controlled trial and economic evaluation of the effects of tranexamic acid on death, vascular occlusive events and transfusion requirement in bleeding trauma patients.
Roberts I, Shakur H, Coats T, Hunt B, Balogun E, Barnetson L, Cook L, Kawahara T, Perel P, Prieto-Merino D, Ramos M, Cairns J, Guerriero C. Roberts I, et al. Health Technol Assess. 2013 Mar;17(10):1-79. doi: 10.3310/hta17100. Health Technol Assess. 2013. PMID: 23477634 Free PMC article. Clinical Trial.
Development and validation of a prognostic model to predict death in patients with traumatic bleeding, and evaluation of the effect of tranexamic acid on mortality according to baseline risk: a secondary analysis of a randomised controlled trial.
Perel P, Prieto-Merino D, Shakur H, Roberts I. Perel P, et al. Health Technol Assess. 2013 Jun;17(24):1-45, v-vi. doi: 10.3310/hta17240. Health Technol Assess. 2013. PMID: 23782457 Free PMC article. Clinical Trial.
Blood pressure lowering and cardiovascular risk.
Roberts I, Prieto-Merino D. Roberts I, et al. Lancet. 2014 Nov 15;384(9956):1745. doi: 10.1016/S0140-6736(14)62067-5. Epub 2014 Nov 14. Lancet. 2014. PMID: 25455242 No abstract available.
Effect of treatment delay on the effectiveness and safety of antifibrinolytics in acute severe haemorrhage: a meta-analysis of individual patient-level data from 40 138 bleeding patients.
Gayet-Ageron A, Prieto-Merino D, Ker K, Shakur H, Ageron FX, Roberts I; Antifibrinolytic Trials Collaboration. Gayet-Ageron A, et al. Lancet. 2018 Jan 13;391(10116):125-132. doi: 10.1016/S0140-6736(17)32455-8. Epub 2017 Nov 7. Lancet. 2018. PMID: 29126600 Free PMC article.
107 results