Prather PL - Search Results

1

7-Azaindolequinuclidinones (7-AIQD): A novel class of cannabinoid 1 (CB1) and cannabinoid 2 (CB2) receptor ligands.

Penthala NR, Shoeib A, Dachavaram SS, Cabanlong CV, Yang J, Zhan CG, Prather PL, Crooks PA. Penthala NR, et al. Among authors: prather pl. Bioorg Med Chem Lett. 2020 Nov 15;30(22):127501. doi: 10.1016/j.bmcl.2020.127501. Epub 2020 Aug 31. Bioorg Med Chem Lett. 2020. PMID: 32882418 Free PMC article.

2

The endocannabinoid noladin ether acts as a full agonist at human CB2 cannabinoid receptors.

Shoemaker JL, Joseph BK, Ruckle MB, Mayeux PR, Prather PL. Shoemaker JL, et al. Among authors: prather pl. J Pharmacol Exp Ther. 2005 Aug;314(2):868-75. doi: 10.1124/jpet.105.085282. Epub 2005 May 18. J Pharmacol Exp Ther. 2005. PMID: 15901805

3

The dietary polyphenols trans-resveratrol and curcumin selectively bind human CB1 cannabinoid receptors with nanomolar affinities and function as antagonists/inverse agonists.

Seely KA, Levi MS, Prather PL. Seely KA, et al. Among authors: prather pl. J Pharmacol Exp Ther. 2009 Jul;330(1):31-9. doi: 10.1124/jpet.109.151654. Epub 2009 Apr 9. J Pharmacol Exp Ther. 2009. PMID: 19359525 Retracted.

4

Phase I hydroxylated metabolites of the K2 synthetic cannabinoid JWH-018 retain in vitro and in vivo cannabinoid 1 receptor affinity and activity.

Brents LK, Reichard EE, Zimmerman SM, Moran JH, Fantegrossi WE, Prather PL. Brents LK, et al. Among authors: prather pl. PLoS One. 2011;6(7):e21917. doi: 10.1371/journal.pone.0021917. Epub 2011 Jul 6. PLoS One. 2011. PMID: 21755008 Free PMC article.

5

Monohydroxylated metabolites of the K2 synthetic cannabinoid JWH-073 retain intermediate to high cannabinoid 1 receptor (CB1R) affinity and exhibit neutral antagonist to partial agonist activity.

Brents LK, Gallus-Zawada A, Radominska-Pandya A, Vasiljevik T, Prisinzano TE, Fantegrossi WE, Moran JH, Prather PL. Brents LK, et al. Among authors: prather pl. Biochem Pharmacol. 2012 Apr 1;83(7):952-61. doi: 10.1016/j.bcp.2012.01.004. Epub 2012 Jan 18. Biochem Pharmacol. 2012. PMID: 22266354 Free PMC article.

6

AM-251 and rimonabant act as direct antagonists at mu-opioid receptors: implications for opioid/cannabinoid interaction studies.

Seely KA, Brents LK, Franks LN, Rajasekaran M, Zimmerman SM, Fantegrossi WE, Prather PL. Seely KA, et al. Among authors: prather pl. Neuropharmacology. 2012 Oct;63(5):905-15. doi: 10.1016/j.neuropharm.2012.06.046. Epub 2012 Jul 4. Neuropharmacology. 2012. PMID: 22771770 Free PMC article.

7

Cytochrome P450-mediated oxidative metabolism of abused synthetic cannabinoids found in K2/Spice: identification of novel cannabinoid receptor ligands.

Chimalakonda KC, Seely KA, Bratton SM, Brents LK, Moran CL, Endres GW, James LP, Hollenberg PF, Prather PL, Radominska-Pandya A, Moran JH. Chimalakonda KC, et al. Among authors: prather pl. Drug Metab Dispos. 2012 Nov;40(11):2174-84. doi: 10.1124/dmd.112.047530. Epub 2012 Aug 17. Drug Metab Dispos. 2012. PMID: 22904561 Free PMC article.

8

Evaluation of (Z)-2-((1-benzyl-1H-indol-3-yl)methylene)-quinuclidin-3-one analogues as novel, high affinity ligands for CB1 and CB2 cannabinoid receptors.

Madadi NR, Penthala NR, Brents LK, Ford BM, Prather PL, Crooks PA. Madadi NR, et al. Among authors: prather pl. Bioorg Med Chem Lett. 2013 Apr 1;23(7):2019-21. doi: 10.1016/j.bmcl.2013.02.025. Epub 2013 Feb 14. Bioorg Med Chem Lett. 2013. PMID: 23466226 Free PMC article.

9

Human metabolites of synthetic cannabinoids JWH-018 and JWH-073 bind with high affinity and act as potent agonists at cannabinoid type-2 receptors.

Rajasekaran M, Brents LK, Franks LN, Moran JH, Prather PL. Rajasekaran M, et al. Among authors: prather pl. Toxicol Appl Pharmacol. 2013 Jun 1;269(2):100-8. doi: 10.1016/j.taap.2013.03.012. Epub 2013 Mar 26. Toxicol Appl Pharmacol. 2013. PMID: 23537664 Free PMC article.

10

Design, synthesis, and biological evaluation of aminoalkylindole derivatives as cannabinoid receptor ligands with potential for treatment of alcohol abuse.

Vasiljevik T, Franks LN, Ford BM, Douglas JT, Prather PL, Fantegrossi WE, Prisinzano TE. Vasiljevik T, et al. Among authors: prather pl. J Med Chem. 2013 Jun 13;56(11):4537-50. doi: 10.1021/jm400268b. Epub 2013 May 22. J Med Chem. 2013. PMID: 23631463 Free PMC article.

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