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Inducible mismatch repair streamlines forward genetic approaches to target identification of cytotoxic small molecules.
Cell Chem Biol. 2023 Nov 16;30(11):1453-1467.e8. doi: 10.1016/j.chembiol.2023.07.017. Epub 2023 Aug 21.
Cell Chem Biol. 2023.
PMID: 37607550
Engineering Forward Genetics into Cultured Cancer Cells for Chemical Target Identification.
Povedano JM, Liou J, Wei D, Srivatsav A, Kim J, Xie Y, Nijhawan D, McFadden DG.
Povedano JM, et al.
Cell Chem Biol. 2019 Sep 19;26(9):1315-1321.e3. doi: 10.1016/j.chembiol.2019.06.006. Epub 2019 Jul 11.
Cell Chem Biol. 2019.
PMID: 31303577
Free PMC article.
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TK216 targets microtubules in Ewing sarcoma cells.
Povedano JM, Li V, Lake KE, Bai X, Rallabandi R, Kim J, Xie Y, De Brabander JK, McFadden DG.
Povedano JM, et al.
Cell Chem Biol. 2022 Aug 18;29(8):1325-1332.e4. doi: 10.1016/j.chembiol.2022.06.002. Epub 2022 Jul 7.
Cell Chem Biol. 2022.
PMID: 35803262
Free PMC article.
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A Multipronged Approach Establishes Covalent Modification of β-Tubulin as the Mode of Action of Benzamide Anti-cancer Toxins.
Povedano JM, Rallabandi R, Bai X, Ye X, Liou J, Chen H, Kim J, Xie Y, Posner B, Rice L, De Brabander JK, McFadden DG.
Povedano JM, et al.
J Med Chem. 2020 Nov 25;63(22):14054-14066. doi: 10.1021/acs.jmedchem.0c01482. Epub 2020 Nov 12.
J Med Chem. 2020.
PMID: 33180487
Free PMC article.
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Mice with Pulmonary Fibrosis Driven by Telomere Dysfunction.
Povedano JM, Martinez P, Flores JM, Mulero F, Blasco MA.
Povedano JM, et al.
Cell Rep. 2015 Jul 14;12(2):286-99. doi: 10.1016/j.celrep.2015.06.028. Epub 2015 Jul 2.
Cell Rep. 2015.
PMID: 26146081
Free article.
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Inducible mismatch repair streamlines forward genetic approaches to target identification of cytotoxic small molecules.
Nguyen TP, Fang M, Kim J, Wang B, Lin E, Khivansara V, Barrows N, Rivera-Cancel G, Goralski M, Cervantes CL, Xie S, Peterson JM, Povedano JM, Antczak MI, Posner BA, McFadden DG, Ready JM, De Brabander JK, Nijhawan D.
Nguyen TP, et al. Among authors: povedano jm.
bioRxiv [Preprint]. 2023 Feb 21:2023.02.21.529401. doi: 10.1101/2023.02.21.529401.
bioRxiv. 2023.
PMID: 36865268
Free PMC article.
Updated.
Preprint.
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Therapeutic effects of telomerase in mice with pulmonary fibrosis induced by damage to the lungs and short telomeres.
Povedano JM, Martinez P, Serrano R, Tejera Á, Gómez-López G, Bobadilla M, Flores JM, Bosch F, Blasco MA.
Povedano JM, et al.
Elife. 2018 Jan 30;7:e31299. doi: 10.7554/eLife.31299.
Elife. 2018.
PMID: 29378675
Free PMC article.
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Telomerase gene therapy rescues telomere length, bone marrow aplasia, and survival in mice with aplastic anemia.
Bär C, Povedano JM, Serrano R, Benitez-Buelga C, Popkes M, Formentini I, Bobadilla M, Bosch F, Blasco MA.
Bär C, et al. Among authors: povedano jm.
Blood. 2016 Apr 7;127(14):1770-9. doi: 10.1182/blood-2015-08-667485. Epub 2016 Feb 22.
Blood. 2016.
PMID: 26903545
Free article.
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