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The characterization of microtubule-stabilizing drugs as possible therapeutic agents for Alzheimer's disease and related tauopathies.
Pharmacol Res. 2011 Apr;63(4):341-51. doi: 10.1016/j.phrs.2010.12.002. Epub 2010 Dec 14.
Pharmacol Res. 2011.
PMID: 21163349
Free PMC article.
Epothilone D improves microtubule density, axonal integrity, and cognition in a transgenic mouse model of tauopathy.
Brunden KR, Zhang B, Carroll J, Yao Y, Potuzak JS, Hogan AM, Iba M, James MJ, Xie SX, Ballatore C, Smith AB 3rd, Lee VM, Trojanowski JQ.
Brunden KR, et al. Among authors: potuzak js.
J Neurosci. 2010 Oct 13;30(41):13861-6. doi: 10.1523/JNEUROSCI.3059-10.2010.
J Neurosci. 2010.
PMID: 20943926
Free PMC article.
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The microtubule-stabilizing agent, epothilone D, reduces axonal dysfunction, neurotoxicity, cognitive deficits, and Alzheimer-like pathology in an interventional study with aged tau transgenic mice.
Zhang B, Carroll J, Trojanowski JQ, Yao Y, Iba M, Potuzak JS, Hogan AM, Xie SX, Ballatore C, Smith AB 3rd, Lee VM, Brunden KR.
Zhang B, et al. Among authors: potuzak js.
J Neurosci. 2012 Mar 14;32(11):3601-11. doi: 10.1523/JNEUROSCI.4922-11.2012.
J Neurosci. 2012.
PMID: 22423084
Free PMC article.
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A Formal Total Synthesis of (-)-Brevisamide.
Smith AB 3rd, Kutsumura N, Potuzak J.
Smith AB 3rd, et al.
Tetrahedron Lett. 2011 Apr 27;52(17):2117-2119. doi: 10.1016/j.tetlet.2010.11.013.
Tetrahedron Lett. 2011.
PMID: 21572531
Free PMC article.
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Discovery and applications of small molecule probes for studying biological processes.
Potuzak JS, Moilanen SB, Tan DS.
Potuzak JS, et al.
Biotechnol Genet Eng Rev. 2004;21:11-78. doi: 10.1080/02648725.2004.10648049.
Biotechnol Genet Eng Rev. 2004.
PMID: 17017027
Review.
No abstract available.
Item in Clipboard
Stereocontrolled synthesis of spiroketals via Ti(Oi-Pr)4-mediated kinetic spirocyclization of glycal epoxides with retention of configuration.
Moilanen SB, Potuzak JS, Tan DS.
Moilanen SB, et al. Among authors: potuzak js.
J Am Chem Soc. 2006 Feb 15;128(6):1792-3. doi: 10.1021/ja057908f.
J Am Chem Soc. 2006.
PMID: 16464069
Free PMC article.
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Stereocontrolled synthesis of spiroketals via a remarkable methanol-induced kinetic spirocyclization reaction.
Potuzak JS, Moilanen SB, Tan DS.
Potuzak JS, et al.
J Am Chem Soc. 2005 Oct 12;127(40):13796-7. doi: 10.1021/ja055033z.
J Am Chem Soc. 2005.
PMID: 16201793
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