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The therapeutically actionable long non-coding RNA 'T-RECS' is essential to cancer cells' survival in NRAS/MAPK-driven melanoma.
Feichtenschlager V, Chen L, Zheng YJ, Ho W, Sanlorenzo M, Vujic I, Fewings E, Lee A, Chen C, Callanan C, Lin K, Qu T, Hohlova D, Vujic M, Hwang Y, Lai K, Chen S, Nguyen T, Muñoz DP, Kohwi Y, Posch C, Daud A, Rappersberger K, Kohwi-Shigematsu T, Coppé JP, Ortiz-Urda S. Feichtenschlager V, et al. Among authors: posch c. Mol Cancer. 2024 Feb 22;23(1):40. doi: 10.1186/s12943-024-01955-7. Mol Cancer. 2024. PMID: 38383439 Free PMC article.
Cryopyrin-associated periodic syndrome.
Posch C, Kaulfersch W, Rappersberger K. Posch C, et al. Pediatr Dermatol. 2014 Mar-Apr;31(2):228-31. doi: 10.1111/j.1525-1470.2012.01812.x. Epub 2012 Aug 14. Pediatr Dermatol. 2014. PMID: 22891689
Combined targeting of MEK and PI3K/mTOR effector pathways is necessary to effectively inhibit NRAS mutant melanoma in vitro and in vivo.
Posch C, Moslehi H, Feeney L, Green GA, Ebaee A, Feichtenschlager V, Chong K, Peng L, Dimon MT, Phillips T, Daud AI, McCalmont TH, LeBoit PE, Ortiz-Urda S. Posch C, et al. Proc Natl Acad Sci U S A. 2013 Mar 5;110(10):4015-20. doi: 10.1073/pnas.1216013110. Epub 2013 Feb 19. Proc Natl Acad Sci U S A. 2013. PMID: 23431193 Free PMC article.
NRAS mutant melanoma--undrugable?
Posch C, Ortiz-Urda S. Posch C, et al. Oncotarget. 2013 Apr;4(4):494-5. doi: 10.18632/oncotarget.970. Oncotarget. 2013. PMID: 23660168 Free PMC article. Review.
Melanoma immunotherapy.
Sanlorenzo M, Vujic I, Posch C, Dajee A, Yen A, Kim S, Ashworth M, Rosenblum MD, Algazi A, Osella-Abate S, Quaglino P, Daud A, Ortiz-Urda S. Sanlorenzo M, et al. Among authors: posch c. Cancer Biol Ther. 2014 Jun 1;15(6):665-74. doi: 10.4161/cbt.28555. Epub 2014 Mar 20. Cancer Biol Ther. 2014. PMID: 24651672 Free PMC article. Review.
162 results