Pos KM - Search Results

1

Pyridylpiperazine-based allosteric inhibitors of RND-type multidrug efflux pumps.

Plé C, Tam HK, Vieira Da Cruz A, Compagne N, Jiménez-Castellanos JC, Müller RT, Pradel E, Foong WE, Malloci G, Ballée A, Kirchner MA, Moshfegh P, Herledan A, Herrmann A, Deprez B, Willand N, Vargiu AV, Pos KM, Flipo M, Hartkoorn RC. Plé C, et al. Among authors: pos km. Nat Commun. 2022 Jan 10;13(1):115. doi: 10.1038/s41467-021-27726-2. Nat Commun. 2022. PMID: 35013254 Free PMC article.

2

Drug transport mechanism of the AcrB efflux pump.

Pos KM. Pos KM. Biochim Biophys Acta. 2009 May;1794(5):782-93. doi: 10.1016/j.bbapap.2008.12.015. Epub 2009 Jan 3. Biochim Biophys Acta. 2009. PMID: 19166984 Review.

3

Effect of the F610A mutation on substrate extrusion in the AcrB transporter: explanation and rationale by molecular dynamics simulations.

Vargiu AV, Collu F, Schulz R, Pos KM, Zacharias M, Kleinekathöfer U, Ruggerone P. Vargiu AV, et al. Among authors: pos km. J Am Chem Soc. 2011 Jul 20;133(28):10704-7. doi: 10.1021/ja202666x. Epub 2011 Jun 27. J Am Chem Soc. 2011. PMID: 21707050

4

Detecting substrates bound to the secondary multidrug efflux pump EmrE by DNP-enhanced solid-state NMR.

Ong YS, Lakatos A, Becker-Baldus J, Pos KM, Glaubitz C. Ong YS, et al. Among authors: pos km. J Am Chem Soc. 2013 Oct 23;135(42):15754-62. doi: 10.1021/ja402605s. Epub 2013 Oct 11. J Am Chem Soc. 2013. PMID: 24047229

5

RND efflux pumps: structural information translated into function and inhibition mechanisms.

Ruggerone P, Murakami S, Pos KM, Vargiu AV. Ruggerone P, et al. Among authors: pos km. Curr Top Med Chem. 2013;13(24):3079-100. doi: 10.2174/15680266113136660220. Curr Top Med Chem. 2013. PMID: 24200360 Review.

6

Switch-loop flexibility affects transport of large drugs by the promiscuous AcrB multidrug efflux transporter.

Cha HJ, Müller RT, Pos KM. Cha HJ, et al. Among authors: pos km. Antimicrob Agents Chemother. 2014 Aug;58(8):4767-72. doi: 10.1128/AAC.02733-13. Epub 2014 Jun 9. Antimicrob Agents Chemother. 2014. PMID: 24914123 Free PMC article.

7

Coupling of remote alternating-access transport mechanisms for protons and substrates in the multidrug efflux pump AcrB.

Eicher T, Seeger MA, Anselmi C, Zhou W, Brandstätter L, Verrey F, Diederichs K, Faraldo-Gómez JD, Pos KM. Eicher T, et al. Among authors: pos km. Elife. 2014 Sep 19;3:e03145. doi: 10.7554/eLife.03145. Elife. 2014. PMID: 25248080 Free PMC article.

8

The assembly and disassembly of the AcrAB-TolC three-component multidrug efflux pump.

Müller RT, Pos KM. Müller RT, et al. Among authors: pos km. Biol Chem. 2015 Sep;396(9-10):1083-9. doi: 10.1515/hsz-2015-0150. Biol Chem. 2015. PMID: 26061621 Review.

9

Molecular basis of polyspecificity of the Small Multidrug Resistance Efflux Pump AbeS from Acinetobacter baumannii.

Lytvynenko I, Brill S, Oswald C, Pos KM. Lytvynenko I, et al. Among authors: pos km. J Mol Biol. 2016 Feb 13;428(3):644-657. doi: 10.1016/j.jmb.2015.12.006. Epub 2015 Dec 18. J Mol Biol. 2016. PMID: 26707198

10

Tripartite assembly of RND multidrug efflux pumps.

Daury L, Orange F, Taveau JC, Verchère A, Monlezun L, Gounou C, Marreddy RK, Picard M, Broutin I, Pos KM, Lambert O. Daury L, et al. Among authors: pos km. Nat Commun. 2016 Feb 12;7:10731. doi: 10.1038/ncomms10731. Nat Commun. 2016. PMID: 26867482 Free PMC article.

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