Porazinski S - Search Results

1

Substrate-biased activity-based probes identify proteases that cleave receptor CDCP1.

Kryza T, Khan T, Lovell S, Harrington BS, Yin J, Porazinski S, Pajic M, Koistinen H, Rantala JK, Dreyer T, Magdolen V, Reuning U, He Y, Tate EW, Hooper JD. Kryza T, et al. Among authors: porazinski s. Nat Chem Biol. 2021 Jul;17(7):776-783. doi: 10.1038/s41589-021-00783-w. Epub 2021 Apr 15. Nat Chem Biol. 2021. PMID: 33859413

2

Rho-ROCK Signaling in Normal Physiology and as a Key Player in Shaping the Tumor Microenvironment.

Porazinski S, Parkin A, Pajic M. Porazinski S, et al. Adv Exp Med Biol. 2020;1223:99-127. doi: 10.1007/978-3-030-35582-1_6. Adv Exp Med Biol. 2020. PMID: 32030687 Review.

3

TLR2 activation promotes tumour growth and associates with patient survival and chemotherapy response in pancreatic ductal adenocarcinoma.

Lundy J, Gearing LJ, Gao H, West AC, McLeod L, Deswaerte V, Yu L, Porazinski S, Pajic M, Hertzog PJ, Croagh D, Jenkins BJ. Lundy J, et al. Among authors: porazinski s. Oncogene. 2021 Oct;40(41):6007-6022. doi: 10.1038/s41388-021-01992-2. Epub 2021 Aug 16. Oncogene. 2021. PMID: 34400766

4

Oral Squamous Cell Carcinoma in Young Patients Show Higher Rates of EGFR Amplification: Implications for Novel Personalized Therapy.

Satgunaseelan L, Porazinski S, Strbenac D, Istadi A, Willet C, Chew T, Sadsad R, Palme CE, Lee JH, Boyer M, Yang JYH, Clark JR, Pajic M, Gupta R. Satgunaseelan L, et al. Among authors: porazinski s. Front Oncol. 2021 Nov 29;11:750852. doi: 10.3389/fonc.2021.750852. eCollection 2021. Front Oncol. 2021. PMID: 34912708 Free PMC article.

5

Targeting the ERG oncogene with splice-switching oligonucleotides as a novel therapeutic strategy in prostate cancer.

Li L, Hobson L, Perry L, Clark B, Heavey S, Haider A, Sridhar A, Shaw G, Kelly J, Freeman A, Wilson I, Whitaker H, Nurmemmedov E, Oltean S, Porazinski S, Ladomery M. Li L, et al. Among authors: porazinski s. Br J Cancer. 2020 Sep;123(6):1024-1032. doi: 10.1038/s41416-020-0951-2. Epub 2020 Jun 25. Br J Cancer. 2020. PMID: 32581342 Free PMC article.

6

CDC2-like (CLK) protein kinase inhibition as a novel targeted therapeutic strategy in prostate cancer.

Uzor S, Porazinski SR, Li L, Clark B, Ajiro M, Iida K, Hagiwara M, Alqasem AA, Perks CM, Wilson ID, Oltean S, Ladomery MR. Uzor S, et al. Among authors: porazinski sr. Sci Rep. 2021 Apr 12;11(1):7963. doi: 10.1038/s41598-021-86908-6. Sci Rep. 2021. PMID: 33846420 Free PMC article.

7

EPHA2-dependent outcompetition of KRASG12D mutant cells by wild-type neighbors in the adult pancreas.

Hill W, Zaragkoulias A, Salvador-Barbero B, Parfitt GJ, Alatsatianos M, Padilha A, Porazinski S, Woolley TE, Morton JP, Sansom OJ, Hogan C. Hill W, et al. Among authors: porazinski s. Curr Biol. 2021 Jun 21;31(12):2550-2560.e5. doi: 10.1016/j.cub.2021.03.094. Epub 2021 Apr 22. Curr Biol. 2021. PMID: 33891893 Free PMC article.

8

The oncogenic transcription factor ERG represses the transcription of the tumour suppressor gene PTEN in prostate cancer cells.

Adamo P, Porazinski S, Rajatileka S, Jumbe S, Hagen R, Cheung MK, Wilson I, Ladomery MR. Adamo P, et al. Among authors: porazinski s. Oncol Lett. 2017 Nov;14(5):5605-5610. doi: 10.3892/ol.2017.6841. Epub 2017 Aug 28. Oncol Lett. 2017. PMID: 29113189 Free PMC article.

9

Alternative Splicing in the Hippo Pathway-Implications for Disease and Potential Therapeutic Targets.

Porazinski S, Ladomery M. Porazinski S, et al. Genes (Basel). 2018 Mar 13;9(3):161. doi: 10.3390/genes9030161. Genes (Basel). 2018. PMID: 29534050 Free PMC article. Review.

10

Hypoxia leads to significant changes in alternative splicing and elevated expression of CLK splice factor kinases in PC3 prostate cancer cells.

Bowler E, Porazinski S, Uzor S, Thibault P, Durand M, Lapointe E, Rouschop KMA, Hancock J, Wilson I, Ladomery M. Bowler E, et al. Among authors: porazinski s. BMC Cancer. 2018 Apr 2;18(1):355. doi: 10.1186/s12885-018-4227-7. BMC Cancer. 2018. PMID: 29606096 Free PMC article.

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