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P21-activated kinase 1 (PAK1)-mediated cytoskeleton rearrangement promotes SARS-CoV-2 entry and ACE2 autophagic degradation.
Liu M, Lu B, Li Y, Yuan S, Zhuang Z, Li G, Wang D, Ma L, Zhu J, Zhao J, Chan CC, Poon VK, Chik KK, Zhao Z, Xian H, Zhao J, Zhao J, Chan JF, Zhang Y. Liu M, et al. Among authors: poon vk. Signal Transduct Target Ther. 2023 Oct 9;8(1):385. doi: 10.1038/s41392-023-01631-0. Signal Transduct Target Ther. 2023. PMID: 37806990 Free PMC article.
Robust SARS-CoV-2 infection in nasal turbinates after treatment with systemic neutralizing antibodies.
Zhou D, Chan JF, Zhou B, Zhou R, Li S, Shan S, Liu L, Zhang AJ, Chen SJ, Chan CC, Xu H, Poon VK, Yuan S, Li C, Chik KK, Chan CC, Cao J, Chan CY, Kwan KY, Du Z, Lau TT, Zhang Q, Zhou J, To KK, Zhang L, Ho DD, Yuen KY, Chen Z. Zhou D, et al. Among authors: poon vk. Cell Host Microbe. 2021 Apr 14;29(4):551-563.e5. doi: 10.1016/j.chom.2021.02.019. Epub 2021 Feb 25. Cell Host Microbe. 2021. PMID: 33657424 Free PMC article.
SARS-CoV-2 infection induces inflammatory bone loss in golden Syrian hamsters.
Qiao W, Lau HE, Xie H, Poon VK, Chan CC, Chu H, Yuan S, Yuen TT, Chik KK, Tsang JO, Chan CC, Cai JP, Luo C, Yuen KY, Cheung KM, Chan JF, Yeung KW. Qiao W, et al. Among authors: poon vk. Nat Commun. 2022 May 9;13(1):2539. doi: 10.1038/s41467-022-30195-w. Nat Commun. 2022. PMID: 35534483 Free PMC article.
The spike receptor-binding motif G496S substitution determines the replication fitness of SARS-CoV-2 Omicron sublineage.
Liang R, Ye ZW, Ong CP, Qin Z, Xie Y, Fan Y, Tang K, Poon VK, Chan CC, Yang X, Cao H, Wang K, Sun H, Hu B, Cai JP, Luo C, Chik KK, Chu H, Zheng Y, Yuen KY, Chan JF, Jin DY, Yuan S. Liang R, et al. Among authors: poon vk. Emerg Microbes Infect. 2022 Dec;11(1):2093-2101. doi: 10.1080/22221751.2022.2111977. Emerg Microbes Infect. 2022. PMID: 35943779 Free PMC article.
The celecoxib derivative kinase inhibitor AR-12 (OSU-03012) inhibits Zika virus via down-regulation of the PI3K/Akt pathway and protects Zika virus-infected A129 mice: A host-targeting treatment strategy.
Chan JF, Zhu Z, Chu H, Yuan S, Chik KK, Chan CC, Poon VK, Yip CC, Zhang X, Tsang JO, Zou Z, Tee KM, Shuai H, Lu G, Yuen KY. Chan JF, et al. Among authors: poon vk. Antiviral Res. 2018 Dec;160:38-47. doi: 10.1016/j.antiviral.2018.10.007. Epub 2018 Oct 13. Antiviral Res. 2018. PMID: 30326204 Free PMC article.
Clofazimine broadly inhibits coronaviruses including SARS-CoV-2.
Yuan S, Yin X, Meng X, Chan JF, Ye ZW, Riva L, Pache L, Chan CC, Lai PM, Chan CC, Poon VK, Lee AC, Matsunaga N, Pu Y, Yuen CK, Cao J, Liang R, Tang K, Sheng L, Du Y, Xu W, Lau CY, Sit KY, Au WK, Wang R, Zhang YY, Tang YD, Clausen TM, Pihl J, Oh J, Sze KH, Zhang AJ, Chu H, Kok KH, Wang D, Cai XH, Esko JD, Hung IF, Li RA, Chen H, Sun H, Jin DY, Sun R, Chanda SK, Yuen KY. Yuan S, et al. Among authors: poon vk. Nature. 2021 May;593(7859):418-423. doi: 10.1038/s41586-021-03431-4. Epub 2021 Mar 16. Nature. 2021. PMID: 33727703
70 results