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Mammals divert endogenous genotoxic formaldehyde into one-carbon metabolism.
Burgos-Barragan G, Wit N, Meiser J, Dingler FA, Pietzke M, Mulderrig L, Pontel LB, Rosado IV, Brewer TF, Cordell RL, Monks PS, Chang CJ, Vazquez A, Patel KJ. Burgos-Barragan G, et al. Among authors: pontel lb. Nature. 2017 Aug 31;548(7669):549-554. doi: 10.1038/nature23481. Epub 2017 Aug 16. Nature. 2017. PMID: 28813411 Free PMC article.
Erratum: Mammals divert endogenous genotoxic formaldehyde into one-carbon metabolism.
Burgos-Barragan G, Wit N, Meiser J, Dingler FA, Pietzke M, Mulderrig L, Pontel LB, Rosado IV, Brewer TF, Cordell RL, Monks PS, Chang CJ, Vazquez A, Patel KJ. Burgos-Barragan G, et al. Among authors: pontel lb. Nature. 2017 Aug 31;548(7669):612. doi: 10.1038/nature23904. Epub 2017 Aug 23. Nature. 2017. PMID: 29411778 Free PMC article.
Two Aldehyde Clearance Systems Are Essential to Prevent Lethal Formaldehyde Accumulation in Mice and Humans.
Dingler FA, Wang M, Mu A, Millington CL, Oberbeck N, Watcham S, Pontel LB, Kamimae-Lanning AN, Langevin F, Nadler C, Cordell RL, Monks PS, Yu R, Wilson NK, Hira A, Yoshida K, Mori M, Okamoto Y, Okuno Y, Muramatsu H, Shiraishi Y, Kobayashi M, Moriguchi T, Osumi T, Kato M, Miyano S, Ito E, Kojima S, Yabe H, Yabe M, Matsuo K, Ogawa S, Göttgens B, Hodskinson MRG, Takata M, Patel KJ. Dingler FA, et al. Among authors: pontel lb. Mol Cell. 2020 Dec 17;80(6):996-1012.e9. doi: 10.1016/j.molcel.2020.10.012. Epub 2020 Nov 3. Mol Cell. 2020. PMID: 33147438 Free PMC article.
The toxic side of one-carbon metabolism and epigenetics.
Morellato AE, Umansky C, Pontel LB. Morellato AE, et al. Among authors: pontel lb. Redox Biol. 2021 Apr;40:101850. doi: 10.1016/j.redox.2020.101850. Epub 2020 Dec 28. Redox Biol. 2021. PMID: 33418141 Free PMC article.
Illuminating cellular formaldehyde.
Umansky C, Morellato AE, Pontel LB. Umansky C, et al. Among authors: pontel lb. Nat Commun. 2021 Jan 25;12(1):580. doi: 10.1038/s41467-020-20758-0. Nat Commun. 2021. PMID: 33495466 Free PMC article.
Formaldehyde regulates S-adenosylmethionine biosynthesis and one-carbon metabolism.
Pham VN, Bruemmer KJ, Toh JDW, Ge EJ, Tenney L, Ward CC, Dingler FA, Millington CL, Garcia-Prieto CA, Pulos-Holmes MC, Ingolia NT, Pontel LB, Esteller M, Patel KJ, Nomura DK, Chang CJ. Pham VN, et al. Among authors: pontel lb. Science. 2023 Nov 3;382(6670):eabp9201. doi: 10.1126/science.abp9201. Epub 2023 Nov 3. Science. 2023. PMID: 37917677
20 results