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Repetitive use of levosimendan in advanced heart failure: need for stronger evidence in a field in dire need of a useful therapy.
Pölzl G, Altenberger J, Baholli L, Beltrán P, Borbély A, Comin-Colet J, Delgado JF, Fedele F, Fontana A, Fruhwald F, Giamouzis G, Giannakoulas G, Garcia-González MJ, Gustafsson F, Kaikkonen K, Kivikko M, Kubica J, von Lewinski D, Löfman I, Malfatto G, Manito N, Martínez-Sellés M, Masip J, Merkely B, Morandi F, Mølgaard H, Oliva F, Pantev E, Papp Z, Perna GP, Pfister R, Piazza V, Bover R, Rangel-Sousa D, Recio-Mayoral A, Reinecke A, Rieth A, Sarapohja T, Schmidt G, Seidel M, Störk S, Vrtovec B, Wikström G, Yerly P, Pollesello P. Pölzl G, et al. Among authors: pollesello p. Int J Cardiol. 2017 Sep 15;243:389-395. doi: 10.1016/j.ijcard.2017.05.081. Epub 2017 May 23. Int J Cardiol. 2017. PMID: 28571618 Free article. Review.
Positive inotropic effect of levosimendan is correlated to its stereoselective Ca2+-sensitizing effect but not to stereoselective phosphodiesterase inhibition.
Kaheinen P, Pollesello P, Hertelendi Z, Borbély A, Szilágyi S, Nissinen E, Haikala H, Papp Z. Kaheinen P, et al. Among authors: pollesello p. Basic Clin Pharmacol Toxicol. 2006 Jan;98(1):74-8. doi: 10.1111/j.1742-7843.2006.pto_231.x. Basic Clin Pharmacol Toxicol. 2006. PMID: 16433895 Free article.
137 results