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New Insights into Bitopic Orthosteric/Allosteric Ligands of Cannabinoid Receptor Type 2.
Ferrisi R, Polini B, Ricardi C, Gado F, Mohamed KA, Baron G, Faiella S, Poli G, Rapposelli S, Saccomanni G, Aldini G, Chiellini G, Laprairie RB, Manera C, Ortore G. Ferrisi R, et al. Among authors: poli g. Int J Mol Sci. 2023 Jan 21;24(3):2135. doi: 10.3390/ijms24032135. Int J Mol Sci. 2023. PMID: 36768458 Free PMC article.
Identification of new Fyn kinase inhibitors using a FLAP-based approach.
Poli G, Tuccinardi T, Rizzolio F, Caligiuri I, Botta L, Granchi C, Ortore G, Minutolo F, Schenone S, Martinelli A. Poli G, et al. J Chem Inf Model. 2013 Oct 28;53(10):2538-47. doi: 10.1021/ci4002553. Epub 2013 Sep 16. J Chem Inf Model. 2013. PMID: 24001328
The Extra-Virgin Olive Oil Polyphenols Oleocanthal and Oleacein Counteract Inflammation-Related Gene and miRNA Expression in Adipocytes by Attenuating NF-κB Activation.
Carpi S, Scoditti E, Massaro M, Polini B, Manera C, Digiacomo M, Esposito Salsano J, Poli G, Tuccinardi T, Doccini S, Santorelli FM, Carluccio MA, Macchia M, Wabitsch M, De Caterina R, Nieri P. Carpi S, et al. Among authors: poli g. Nutrients. 2019 Nov 21;11(12):2855. doi: 10.3390/nu11122855. Nutrients. 2019. PMID: 31766503 Free PMC article.
The endocannabinoid system dual-target ligand N-cycloheptyl-1,2-dihydro-5-bromo-1-(4-fluorobenzyl)-6-methyl-2-oxo-pyridine-3-carboxamide improves disease severity in a mouse model of multiple sclerosis.
Arena C, Gado F, Di Cesare Mannelli L, Cervetto C, Carpi S, Reynoso-Moreno I, Polini B, Vallini E, Chicca S, Lucarini E, Bertini S, D'Andrea F, Digiacomo M, Poli G, Tuccinardi T, Macchia M, Gertsch J, Marcoli M, Nieri P, Ghelardini C, Chicca A, Manera C. Arena C, et al. Among authors: poli g. Eur J Med Chem. 2020 Dec 15;208:112858. doi: 10.1016/j.ejmech.2020.112858. Epub 2020 Sep 29. Eur J Med Chem. 2020. PMID: 33002735
Virtual screening and crystallographic studies reveal an unexpected γ-lactone derivative active against MptpB as a potential antitubercular agent.
Cazzaniga G, Mori M, Meneghetti F, Chiarelli LR, Stelitano G, Caligiuri I, Rizzolio F, Ciceri S, Poli G, Staver D, Ortore G, Tuccinardi T, Villa S. Cazzaniga G, et al. Among authors: poli g. Eur J Med Chem. 2022 Apr 15;234:114235. doi: 10.1016/j.ejmech.2022.114235. Epub 2022 Mar 5. Eur J Med Chem. 2022. PMID: 35286928
928 results