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Dual-Acting Small Molecules: Subtype-Selective Cannabinoid Receptor 2 Agonist/Butyrylcholinesterase Inhibitor Hybrids Show Neuroprotection in an Alzheimer's Disease Mouse Model.
Spatz P, Steinmüller SAM, Tutov A, Poeta E, Morilleau A, Carles A, Deventer MH, Hofmann J, Stove CP, Monti B, Maurice T, Decker M. Spatz P, et al. Among authors: poeta e. J Med Chem. 2023 May 11;66(9):6414-6435. doi: 10.1021/acs.jmedchem.3c00541. Epub 2023 Apr 26. J Med Chem. 2023. PMID: 37127287 Free PMC article.
Tacrine-O-protected phenolics heterodimers as multitarget-directed ligands against Alzheimer's disease: Selective subnanomolar BuChE inhibitors.
Roldán-Peña JM, Romero-Real V, Hicke J, Maya I, Franconetti A, Lagunes I, Padrón JM, Petralla S, Poeta E, Naldi M, Bartolini M, Monti B, Bolognesi ML, López Ó, Fernández-Bolaños JG. Roldán-Peña JM, et al. Among authors: poeta e. Eur J Med Chem. 2019 Nov 1;181:111550. doi: 10.1016/j.ejmech.2019.07.053. Epub 2019 Jul 22. Eur J Med Chem. 2019. PMID: 31376562
Dual-Acting Cholinesterase-Human Cannabinoid Receptor 2 Ligands Show Pronounced Neuroprotection in Vitro and Overadditive and Disease-Modifying Neuroprotective Effects in Vivo.
Scheiner M, Dolles D, Gunesch S, Hoffmann M, Nabissi M, Marinelli O, Naldi M, Bartolini M, Petralla S, Poeta E, Monti B, Falkeis C, Vieth M, Hübner H, Gmeiner P, Maitra R, Maurice T, Decker M. Scheiner M, et al. Among authors: poeta e. J Med Chem. 2019 Oct 24;62(20):9078-9102. doi: 10.1021/acs.jmedchem.9b00623. Epub 2019 Oct 14. J Med Chem. 2019. PMID: 31609608 Free PMC article.
Melatonin- and Ferulic Acid-Based HDAC6 Selective Inhibitors Exhibit Pronounced Immunomodulatory Effects In Vitro and Neuroprotective Effects in a Pharmacological Alzheimer's Disease Mouse Model.
He F, Chou CJ, Scheiner M, Poeta E, Yuan Chen N, Gunesch S, Hoffmann M, Sotriffer C, Monti B, Maurice T, Decker M. He F, et al. Among authors: poeta e. J Med Chem. 2021 Apr 8;64(7):3794-3812. doi: 10.1021/acs.jmedchem.0c01940. Epub 2021 Mar 26. J Med Chem. 2021. PMID: 33769811
Selective Pseudo-irreversible Butyrylcholinesterase Inhibitors Transferring Antioxidant Moieties to the Enzyme Show Pronounced Neuroprotective Efficacy In Vitro and In Vivo in an Alzheimer's Disease Mouse Model.
Scheiner M, Hoffmann M, He F, Poeta E, Chatonnet A, Monti B, Maurice T, Decker M. Scheiner M, et al. Among authors: poeta e. J Med Chem. 2021 Jul 8;64(13):9302-9320. doi: 10.1021/acs.jmedchem.1c00534. Epub 2021 Jun 21. J Med Chem. 2021. PMID: 34152756
Discovery of Dual Aβ/Tau Inhibitors and Evaluation of Their Therapeutic Effect on a Drosophila Model of Alzheimer's Disease.
Gandini A, Gonçalves AE, Strocchi S, Albertini C, Janočková J, Tramarin A, Grifoni D, Poeta E, Soukup O, Muñoz-Torrero D, Monti B, Sabaté R, Bartolini M, Legname G, Bolognesi ML. Gandini A, et al. Among authors: poeta e. ACS Chem Neurosci. 2022 Dec 7;13(23):3314-3329. doi: 10.1021/acschemneuro.2c00357. Epub 2022 Nov 29. ACS Chem Neurosci. 2022. PMID: 36445009 Free PMC article.
Targeted quantitative metabolic profiling of brain-derived cell cultures by semi-automated MEPS and LC-MS/MS.
Protti M, Cirrincione M, Palano S, Poeta E, Babini G, Magnifico MC, Barile SN, Balboni N, Massenzio F, Mahdavijalal M, Giorgi FM, Mandrioli R, Lasorsa FM, Monti B, Mercolini L. Protti M, et al. Among authors: poeta e. J Pharm Biomed Anal. 2023 Nov 30;236:115757. doi: 10.1016/j.jpba.2023.115757. Epub 2023 Sep 29. J Pharm Biomed Anal. 2023. PMID: 37801818 Free article.
Deficiency of Mitochondrial Aspartate-Glutamate Carrier 1 Leads to Oligodendrocyte Precursor Cell Proliferation Defects Both In Vitro and In Vivo.
Petralla S, Peña-Altamira LE, Poeta E, Massenzio F, Virgili M, Barile SN, Sbano L, Profilo E, Corricelli M, Danese A, Giorgi C, Ostan R, Capri M, Pinton P, Palmieri F, Lasorsa FM, Monti B. Petralla S, et al. Among authors: poeta e. Int J Mol Sci. 2019 Sep 11;20(18):4486. doi: 10.3390/ijms20184486. Int J Mol Sci. 2019. PMID: 31514314 Free PMC article.
14 results