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HLA-DPA1*02:01~B1*01:01 is a risk haplotype for primary sclerosing cholangitis mediating activation of NKp44+ NK cells.
Zecher BF, Ellinghaus D, Schloer S, Niehrs A, Padoan B, Baumdick ME, Yuki Y, Martin MP, Glow D, Schröder-Schwarz J, Niersch J, Brias S, Müller LM, Habermann R, Kretschmer P, Früh T, Dänekas J, Wehmeyer MH, Poch T, Sebode M; International PSC Study Group (IPSCSG); Ellinghaus E, Degenhardt F, Körner C, Hoelzemer A, Fehse B, Oldhafer KJ, Schumacher U, Sauter G, Carrington M, Franke A, Bunders MJ, Schramm C, Altfeld M. Zecher BF, et al. Among authors: poch t. Gut. 2024 Jan 5;73(2):325-337. doi: 10.1136/gutjnl-2023-329524. Gut. 2024. PMID: 37788895 Free PMC article.
The co-inhibitory receptor TIGIT regulates NK cell function and is upregulated in human intrahepatic CD56bright NK cells.
Ziegler AE, Fittje P, Müller LM, Ahrenstorf AE, Hagemann K, Hagen SH, Hess LU, Niehrs A, Poch T, Ravichandran G, Löbl SM, Padoan B, Brias S, Hennesen J, Richard M, Richert L, Peine S, Oldhafer KJ, Fischer L, Schramm C, Martrus G, Bunders MJ, Altfeld M, Lunemann S. Ziegler AE, et al. Among authors: poch t. Front Immunol. 2023 Feb 9;14:1117320. doi: 10.3389/fimmu.2023.1117320. eCollection 2023. Front Immunol. 2023. PMID: 36845105 Free PMC article.
Human liver-derived CXCR6+ NK cells are predominantly educated through NKG2A and show reduced cytokine production.
Lunemann S, Langeneckert AE, Martrus G, Hess LU, Salzberger W, Ziegler AE, Löbl SM, Poch T, Ravichandran G, Sauter J, Schmidt AH, Schramm C, Oldhafer KJ, Altfeld M, Körner C. Lunemann S, et al. Among authors: poch t. J Leukoc Biol. 2019 Jun;105(6):1331-1340. doi: 10.1002/JLB.1MA1118-428R. Epub 2019 Feb 19. J Leukoc Biol. 2019. PMID: 30779432
CCL21-expression and accumulation of CCR7+ NK cells in livers of patients with primary sclerosing cholangitis.
Langeneckert AE, Lunemann S, Martrus G, Salzberger W, Hess LU, Ziegler AE, Poch T, Ravichandran G, Matschl U, Bosse JB, Tiegs G, Fischer L, Koch M, Herkel J, Oldhafer KJ, Schramm C, Altfeld M. Langeneckert AE, et al. Among authors: poch t. Eur J Immunol. 2019 May;49(5):758-769. doi: 10.1002/eji.201847965. Epub 2019 Feb 27. Eur J Immunol. 2019. PMID: 30785638 Free article.
Interferon-γ-dependent immune responses contribute to the pathogenesis of sclerosing cholangitis in mice.
Ravichandran G, Neumann K, Berkhout LK, Weidemann S, Langeneckert AE, Schwinge D, Poch T, Huber S, Schiller B, Hess LU, Ziegler AE, Oldhafer KJ, Barikbin R, Schramm C, Altfeld M, Tiegs G. Ravichandran G, et al. Among authors: poch t. J Hepatol. 2019 Oct;71(4):773-782. doi: 10.1016/j.jhep.2019.05.023. Epub 2019 Jun 5. J Hepatol. 2019. PMID: 31173810
Single-cell atlas of hepatic T cells reveals expansion of liver-resident naive-like CD4+ T cells in primary sclerosing cholangitis.
Poch T, Krause J, Casar C, Liwinski T, Glau L, Kaufmann M, Ahrenstorf AE, Hess LU, Ziegler AE, Martrus G, Lunemann S, Sebode M, Li J, Schwinge D, Krebs CF, Franke A, Friese MA, Oldhafer KJ, Fischer L, Altfeld M, Lohse AW, Huber S, Tolosa E, Gagliani N, Schramm C. Poch T, et al. J Hepatol. 2021 Aug;75(2):414-423. doi: 10.1016/j.jhep.2021.03.016. Epub 2021 Mar 24. J Hepatol. 2021. PMID: 33774059 Free PMC article.
Tissue-resident NK cells differ in their expression profile of the nutrient transporters Glut1, CD98 and CD71.
Salzberger W, Martrus G, Bachmann K, Goebels H, Heß L, Koch M, Langeneckert A, Lunemann S, Oldhafer KJ, Pfeifer C, Poch T, Richert L, Schramm C, Wahib R, Bunders MJ, Altfeld M. Salzberger W, et al. Among authors: poch t. PLoS One. 2018 Jul 20;13(7):e0201170. doi: 10.1371/journal.pone.0201170. eCollection 2018. PLoS One. 2018. PMID: 30028872 Free PMC article.
Proliferative capacity exhibited by human liver-resident CD49a+CD25+ NK cells.
Martrus G, Kautz T, Lunemann S, Richert L, Glau L, Salzberger W, Goebels H, Langeneckert A, Hess L, Poch T, Schramm C, Oldhafer KJ, Koch M, Tolosa E, Nashan B, Altfeld M. Martrus G, et al. Among authors: poch t. PLoS One. 2017 Aug 9;12(8):e0182532. doi: 10.1371/journal.pone.0182532. eCollection 2017. PLoS One. 2017. PMID: 28792982 Free PMC article.
Interactions Between KIR3DS1 and HLA-F Activate Natural Killer Cells to Control HCV Replication in Cell Culture.
Lunemann S, Schöbel A, Kah J, Fittje P, Hölzemer A, Langeneckert AE, Hess LU, Poch T, Martrus G, Garcia-Beltran WF, Körner C, Ziegler AE, Richert L, Oldhafer KJ, Schulze Zur Wiesch J, Schramm C, Dandri M, Herker E, Altfeld M. Lunemann S, et al. Among authors: poch t. Gastroenterology. 2018 Nov;155(5):1366-1371.e3. doi: 10.1053/j.gastro.2018.07.019. Epub 2018 Jul 19. Gastroenterology. 2018. PMID: 30031767
CD49a Expression Identifies a Subset of Intrahepatic Macrophages in Humans.
Martrus G, Goebels H, Langeneckert AE, Kah J, Flomm F, Ziegler AE, Niehrs A, Löbl SM, Russu K, Hess LU, Salzberger W, Poch T, Nashan B, Schramm C, Oldhafer KJ, Dandri M, Koch M, Lunemann S, Altfeld M. Martrus G, et al. Among authors: poch t. Front Immunol. 2019 Jun 7;10:1247. doi: 10.3389/fimmu.2019.01247. eCollection 2019. Front Immunol. 2019. PMID: 31231382 Free PMC article.
63 results