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ZFYVE21 is a complement-induced Rab5 effector that activates non-canonical NF-κB via phosphoinosotide remodeling of endosomes.
Fang C, Manes TD, Liu L, Liu K, Qin L, Li G, Tobiasova Z, Kirkiles-Smith NC, Patel M, Merola J, Fu W, Liu R, Xie C, Tietjen GT, Nigrovic PA, Tellides G, Pober JS, Jane-Wit D. Fang C, et al. Among authors: pober js. Nat Commun. 2019 May 21;10(1):2247. doi: 10.1038/s41467-019-10041-2. Nat Commun. 2019. PMID: 31113953 Free PMC article.
Hedgehog-induced ZFYVE21 promotes chronic vascular inflammation by activating NLRP3 inflammasomes in T cells.
Jiang B, Wang S, Song G, Jiang Q, Fan M, Fang C, Li X, Soh CL, Manes TD, Cheru N, Qin L, Ren P, Jortner B, Wang Q, Quaranta E, Yoo P, Geirsson A, Davis RP, Tellides G, Pober JS, Jane-Wit D. Jiang B, et al. Among authors: pober js. Sci Signal. 2023 Mar 21;16(777):eabo3406. doi: 10.1126/scisignal.abo3406. Epub 2023 Mar 21. Sci Signal. 2023. PMID: 36943921 Free PMC article.
Endothelial Cell-Derived Interleukin-18 Released During Ischemia Reperfusion Injury Selectively Expands T Peripheral Helper Cells to Promote Alloantibody Production.
Liu L, Fang C, Fu W, Jiang B, Li G, Qin L, Rosenbluth J, Gong G, Xie CB, Yoo P, Tellides G, Pober JS, Jane-Wit D. Liu L, et al. Among authors: pober js. Circulation. 2020 Feb 11;141(6):464-478. doi: 10.1161/CIRCULATIONAHA.119.042501. Epub 2019 Nov 20. Circulation. 2020. PMID: 31744330 Free PMC article.
402 results