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GPIHBP1 and Plasma Triglyceride Metabolism.
Fong LG, Young SG, Beigneux AP, Bensadoun A, Oberer M, Jiang H, Ploug M. Fong LG, et al. Among authors: ploug m. Trends Endocrinol Metab. 2016 Jul;27(7):455-469. doi: 10.1016/j.tem.2016.04.013. Epub 2016 May 14. Trends Endocrinol Metab. 2016. PMID: 27185325 Free PMC article. Review.
Multimerization of glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1 (GPIHBP1) and familial chylomicronemia from a serine-to-cysteine substitution in GPIHBP1 Ly6 domain.
Plengpanich W, Young SG, Khovidhunkit W, Bensadoun A, Karnman H, Ploug M, Gårdsvoll H, Leung CS, Adeyo O, Larsson M, Muanpetch S, Charoen S, Fong LG, Niramitmahapanya S, Beigneux AP. Plengpanich W, et al. Among authors: ploug m. J Biol Chem. 2014 Jul 11;289(28):19491-9. doi: 10.1074/jbc.M114.558528. Epub 2014 May 20. J Biol Chem. 2014. PMID: 24847059 Free PMC article. Clinical Trial.
An LPL-specific monoclonal antibody, 88B8, that abolishes the binding of LPL to GPIHBP1.
Allan CM, Larsson M, Hu X, He C, Jung RS, Mapar A, Voss C, Miyashita K, Machida T, Murakami M, Nakajima K, Bensadoun A, Ploug M, Fong LG, Young SG, Beigneux AP. Allan CM, et al. Among authors: ploug m. J Lipid Res. 2016 Oct;57(10):1889-1898. doi: 10.1194/jlr.M070813. Epub 2016 Aug 5. J Lipid Res. 2016. PMID: 27494936 Free PMC article.
Monoclonal antibodies that bind to the Ly6 domain of GPIHBP1 abolish the binding of LPL.
Hu X, Sleeman MW, Miyashita K, Linton MF, Allan CM, He C, Larsson M, Tu Y, Sandoval NP, Jung RS, Mapar A, Machida T, Murakami M, Nakajima K, Ploug M, Fong LG, Young SG, Beigneux AP. Hu X, et al. Among authors: ploug m. J Lipid Res. 2017 Jan;58(1):208-215. doi: 10.1194/jlr.M072462. Epub 2016 Nov 15. J Lipid Res. 2017. PMID: 27875259 Free PMC article.
Autoantibodies against GPIHBP1 as a Cause of Hypertriglyceridemia.
Beigneux AP, Miyashita K, Ploug M, Blom DJ, Ai M, Linton MF, Khovidhunkit W, Dufour R, Garg A, McMahon MA, Pullinger CR, Sandoval NP, Hu X, Allan CM, Larsson M, Machida T, Murakami M, Reue K, Tontonoz P, Goldberg IJ, Moulin P, Charrière S, Fong LG, Nakajima K, Young SG. Beigneux AP, et al. Among authors: ploug m. N Engl J Med. 2017 Apr 27;376(17):1647-1658. doi: 10.1056/NEJMoa1611930. Epub 2017 Apr 5. N Engl J Med. 2017. PMID: 28402248 Free PMC article.
165 results