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Immune dysfunction in Niemann-Pick disease type C.
Platt N, Speak AO, Colaco A, Gray J, Smith DA, Williams IM, Wallom KL, Platt FM. Platt N, et al. Among authors: platt fm. J Neurochem. 2016 Jan;136 Suppl 1(Suppl Suppl 1):74-80. doi: 10.1111/jnc.13138. Epub 2015 Jun 4. J Neurochem. 2016. PMID: 25946402 Free PMC article. Review.
Invariant natural killer T cells are not affected by lysosomal storage in patients with Niemann-Pick disease type C.
Speak AO, Platt N, Salio M, te Vruchte D, Smith DA, Shepherd D, Veerapen N, Besra GS, Yanjanin NM, Simmons L, Imrie J, Wraith JE, Lachmann RH, Hartung R, Runz H, Mengel E, Beck M, Hendriksz CJ, Porter FD, Cerundolo V, Platt FM. Speak AO, et al. Among authors: platt fm, platt n. Eur J Immunol. 2012 Jul;42(7):1886-92. doi: 10.1002/eji.201141821. Epub 2012 Jun 14. Eur J Immunol. 2012. PMID: 22585405 Free PMC article.
FTY720/fingolimod increases NPC1 and NPC2 expression and reduces cholesterol and sphingolipid accumulation in Niemann-Pick type C mutant fibroblasts.
Newton J, Hait NC, Maceyka M, Colaco A, Maczis M, Wassif CA, Cougnoux A, Porter FD, Milstien S, Platt N, Platt FM, Spiegel S. Newton J, et al. Among authors: platt fm, platt n. FASEB J. 2017 Apr;31(4):1719-1730. doi: 10.1096/fj.201601041R. Epub 2017 Jan 12. FASEB J. 2017. PMID: 28082351 Free PMC article.
Because neurodegeneration is the main clinical feature of NPC disease, and FTY720 accumulates in the CNS and has several advantages over available histone deacetylase inhibitors now in clinical trials, our work provides a potential opportunity for treatment of this incurable dise …
Because neurodegeneration is the main clinical feature of NPC disease, and FTY720 accumulates in the CNS and has several advantages over ava …
Unbiased yeast screens identify cellular pathways affected in Niemann-Pick disease type C.
Colaco A, Fernández-Suárez ME, Shepherd D, Gal L, Bibi C, Chuartzman S, Diot A, Morten K, Eden E, Porter FD, Poulton J, Platt N, Schuldiner M, Platt FM. Colaco A, et al. Among authors: platt fm, platt n. Life Sci Alliance. 2020 Jun 2;3(7):e201800253. doi: 10.26508/lsa.201800253. Print 2020 Jul. Life Sci Alliance. 2020. PMID: 32487688 Free PMC article.
Impaired antibacterial autophagy links granulomatous intestinal inflammation in Niemann-Pick disease type C1 and XIAP deficiency with NOD2 variants in Crohn's disease.
Schwerd T, Pandey S, Yang HT, Bagola K, Jameson E, Jung J, Lachmann RH, Shah N, Patel SY, Booth C, Runz H, Düker G, Bettels R, Rohrbach M, Kugathasan S, Chapel H, Keshav S, Elkadri A, Platt N, Muise AM, Koletzko S, Xavier RJ, Marquardt T, Powrie F, Wraith JE, Gyrd-Hansen M, Platt FM, Uhlig HH. Schwerd T, et al. Among authors: platt fm, platt n. Gut. 2017 Jun;66(6):1060-1073. doi: 10.1136/gutjnl-2015-310382. Epub 2016 Mar 7. Gut. 2017. PMID: 26953272 Free PMC article.
Pathogenic mycobacteria achieve cellular persistence by inhibiting the Niemann-Pick Type C disease cellular pathway.
Fineran P, Lloyd-Evans E, Lack NA, Platt N, Davis LC, Morgan AJ, Höglinger D, Tatituri RVV, Clark S, Williams IM, Tynan P, Al Eisa N, Nazarova E, Williams A, Galione A, Ory DS, Besra GS, Russell DG, Brenner MB, Sim E, Platt FM. Fineran P, et al. Among authors: platt fm, platt n. Wellcome Open Res. 2016 Nov 18;1:18. doi: 10.12688/wellcomeopenres.10036.2. Wellcome Open Res. 2016. PMID: 28008422 Free PMC article.
Anti-TNF therapy for inflammatory bowel disease in patients with neurodegenerative Niemann-Pick disease Type C.
Williams I, Pandey S, Haller W, Huynh HQ, Chan A, Düeker G, Bettels R, Peyrin-Biroulet L, Dike CR, DeGeeter C, Smith D, Al Eisa N, Platt N, Marquardt T, Schwerd T, Platt FM, Uhlig HH. Williams I, et al. Among authors: platt fm, platt n. Wellcome Open Res. 2022 Jan 11;7:11. doi: 10.12688/wellcomeopenres.16986.1. eCollection 2022. Wellcome Open Res. 2022. PMID: 35694196 Free PMC article.
Implications for invariant natural killer T cell ligands due to the restricted presence of isoglobotrihexosylceramide in mammals.
Speak AO, Salio M, Neville DC, Fontaine J, Priestman DA, Platt N, Heare T, Butters TD, Dwek RA, Trottein F, Exley MA, Cerundolo V, Platt FM. Speak AO, et al. Among authors: platt fm, platt n. Proc Natl Acad Sci U S A. 2007 Apr 3;104(14):5971-6. doi: 10.1073/pnas.0607285104. Epub 2007 Mar 19. Proc Natl Acad Sci U S A. 2007. PMID: 17372214 Free PMC article.
131 results