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XIST directly regulates X-linked and autosomal genes in naive human pluripotent cells.
Dror I, Chitiashvili T, Tan SYX, Cano CT, Sahakyan A, Markaki Y, Chronis C, Collier AJ, Deng W, Liang G, Sun Y, Afasizheva A, Miller J, Xiao W, Black DL, Ding F, Plath K. Dror I, et al. Among authors: plath k. Cell. 2024 Jan 4;187(1):110-129.e31. doi: 10.1016/j.cell.2023.11.033. Cell. 2024. PMID: 38181737 Free article.
Human Naive Pluripotent Stem Cells Model X Chromosome Dampening and X Inactivation.
Sahakyan A, Kim R, Chronis C, Sabri S, Bonora G, Theunissen TW, Kuoy E, Langerman J, Clark AT, Jaenisch R, Plath K. Sahakyan A, et al. Among authors: plath k. Cell Stem Cell. 2017 Jan 5;20(1):87-101. doi: 10.1016/j.stem.2016.10.006. Epub 2016 Dec 15. Cell Stem Cell. 2017. PMID: 27989770 Free PMC article.
The Role of Xist in X-Chromosome Dosage Compensation.
Sahakyan A, Yang Y, Plath K. Sahakyan A, et al. Among authors: plath k. Trends Cell Biol. 2018 Dec;28(12):999-1013. doi: 10.1016/j.tcb.2018.05.005. Epub 2018 Jun 14. Trends Cell Biol. 2018. PMID: 29910081 Free PMC article. Review.
A protein assembly mediates Xist localization and gene silencing.
Pandya-Jones A, Markaki Y, Serizay J, Chitiashvili T, Mancia Leon WR, Damianov A, Chronis C, Papp B, Chen CK, McKee R, Wang XJ, Chau A, Sabri S, Leonhardt H, Zheng S, Guttman M, Black DL, Plath K. Pandya-Jones A, et al. Among authors: plath k. Nature. 2020 Nov;587(7832):145-151. doi: 10.1038/s41586-020-2703-0. Epub 2020 Sep 9. Nature. 2020. PMID: 32908311 Free PMC article.
Xist nucleates local protein gradients to propagate silencing across the X chromosome.
Markaki Y, Gan Chong J, Wang Y, Jacobson EC, Luong C, Tan SYX, Jachowicz JW, Strehle M, Maestrini D, Banerjee AK, Mistry BA, Dror I, Dossin F, Schöneberg J, Heard E, Guttman M, Chou T, Plath K. Markaki Y, et al. Among authors: plath k. Cell. 2021 Dec 9;184(25):6174-6192.e32. doi: 10.1016/j.cell.2021.10.022. Epub 2021 Nov 4. Cell. 2021. PMID: 34813726 Free PMC article.
154 results