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Trapping the HIV-1 V3 loop in a helical conformation enables broad neutralization.
Glögl M, Friedrich N, Cerutti G, Lemmin T, Kwon YD, Gorman J, Maliqi L, Mittl PRE, Hesselman MC, Schmidt D, Weber J, Foulkes C, Dingens AS, Bylund T, Olia AS, Verardi R, Reinberg T, Baumann NS, Rusert P, Dreier B, Shapiro L, Kwong PD, Plückthun A, Trkola A. Glögl M, et al. Among authors: pluckthun a. Nat Struct Mol Biol. 2023 Sep;30(9):1323-1336. doi: 10.1038/s41594-023-01062-z. Epub 2023 Aug 21. Nat Struct Mol Biol. 2023. PMID: 37605043 Free PMC article.
Structure-based optimization of designed Armadillo-repeat proteins.
Madhurantakam C, Varadamsetty G, Grütter MG, Plückthun A, Mittl PR. Madhurantakam C, et al. Among authors: pluckthun a. Protein Sci. 2012 Jul;21(7):1015-28. doi: 10.1002/pro.2085. Epub 2012 May 24. Protein Sci. 2012. PMID: 22544642 Free PMC article.
Structural and functional analysis of phosphorylation-specific binders of the kinase ERK from designed ankyrin repeat protein libraries.
Kummer L, Parizek P, Rube P, Millgramm B, Prinz A, Mittl PR, Kaufholz M, Zimmermann B, Herberg FW, Plückthun A. Kummer L, et al. Among authors: pluckthun a. Proc Natl Acad Sci U S A. 2012 Aug 21;109(34):E2248-57. doi: 10.1073/pnas.1205399109. Epub 2012 Jul 27. Proc Natl Acad Sci U S A. 2012. PMID: 22843676 Free PMC article.
Development of a generic adenovirus delivery system based on structure-guided design of bispecific trimeric DARPin adapters.
Dreier B, Honegger A, Hess C, Nagy-Davidescu G, Mittl PR, Grütter MG, Belousova N, Mikheeva G, Krasnykh V, Plückthun A. Dreier B, et al. Among authors: pluckthun a. Proc Natl Acad Sci U S A. 2013 Mar 5;110(10):E869-77. doi: 10.1073/pnas.1213653110. Epub 2013 Feb 19. Proc Natl Acad Sci U S A. 2013. PMID: 23431166 Free PMC article.
482 results