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An adjuvant strategy enabled by modulation of the physical properties of microbial ligands expands antigen immunogenicity.
Borriello F, Poli V, Shrock E, Spreafico R, Liu X, Pishesha N, Carpenet C, Chou J, Di Gioia M, McGrath ME, Dillen CA, Barrett NA, Lacanfora L, Franco ME, Marongiu L, Iwakura Y, Pucci F, Kruppa MD, Ma Z, Lowman DW, Ensley HE, Nanishi E, Saito Y, O'Meara TR, Seo HS, Dhe-Paganon S, Dowling DJ, Frieman M, Elledge SJ, Levy O, Irvine DJ, Ploegh HL, Williams DL, Zanoni I. Borriello F, et al. Among authors: pishesha n. Cell. 2022 Feb 17;185(4):614-629.e21. doi: 10.1016/j.cell.2022.01.009. Epub 2022 Feb 10. Cell. 2022. PMID: 35148840 Free PMC article.
A guide to antigen processing and presentation.
Pishesha N, Harmand TJ, Ploegh HL. Pishesha N, et al. Nat Rev Immunol. 2022 Dec;22(12):751-764. doi: 10.1038/s41577-022-00707-2. Epub 2022 Apr 13. Nat Rev Immunol. 2022. PMID: 35418563 Review.
An in vivo selection-derived d-peptide for engineering erythrocyte-binding antigens that promote immune tolerance.
Loftis AR, Zhang G, Backlund C, Quartararo AJ, Pishesha N, Hanna CC, Schissel CK, Garafola D, Loas A, Collier RJ, Ploegh H, Irvine DJ, Pentelute BL. Loftis AR, et al. Among authors: pishesha n. Proc Natl Acad Sci U S A. 2021 Aug 24;118(34):e2101596118. doi: 10.1073/pnas.2101596118. Proc Natl Acad Sci U S A. 2021. PMID: 34417313 Free PMC article.
Nanobodies as in vivo, non-invasive, imaging agents.
Harmand TJ, Islam A, Pishesha N, Ploegh HL. Harmand TJ, et al. Among authors: pishesha n. RSC Chem Biol. 2021 Mar 8;2(3):685-701. doi: 10.1039/d1cb00023c. RSC Chem Biol. 2021. PMID: 34212147 Free PMC article. Review.
A class II MHC-targeted vaccine elicits immunity against SARS-CoV-2 and its variants.
Pishesha N, Harmand TJ, Rothlauf PW, Praest P, Alexander RK, van den Doel R, Liebeskind MJ, Vakaki MA, McCaul N, Wijne C, Verhaar E, Pinney W 3rd, Heston H, Bloyet LM, Pontelli MC, Ilagan MXG, Jan Lebbink R, Buchser WJ, Wiertz EJHJ, Whelan SPJ, Ploegh HL. Pishesha N, et al. Proc Natl Acad Sci U S A. 2021 Nov 2;118(44):e2116147118. doi: 10.1073/pnas.2116147118. Proc Natl Acad Sci U S A. 2021. PMID: 34654739 Free PMC article.
Site-Specific Protein Labeling via Sortase-Mediated Transpeptidation.
Antos JM, Ingram J, Fang T, Pishesha N, Truttmann MC, Ploegh HL. Antos JM, et al. Among authors: pishesha n. Curr Protoc Protein Sci. 2017 Aug 1;89:15.3.1-15.3.19. doi: 10.1002/cpps.38. Curr Protoc Protein Sci. 2017. PMID: 28762490 Free PMC article.
31 results