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Page 1
Alarmins MRP8 and MRP14 induce stress tolerance in phagocytes under sterile inflammatory conditions.
Austermann J, Friesenhagen J, Fassl SK, Petersen B, Ortkras T, Burgmann J, Barczyk-Kahlert K, Faist E, Zedler S, Pirr S, Rohde C, Müller-Tidow C, von Köckritz-Blickwede M, von Kaisenberg CS, Flohé SB, Ulas T, Schultze JL, Roth J, Vogl T, Viemann D. Austermann J, et al. Among authors: pirr s. Cell Rep. 2014 Dec 24;9(6):2112-23. doi: 10.1016/j.celrep.2014.11.020. Epub 2014 Dec 11. Cell Rep. 2014. PMID: 25497086 Free article.
In neonates S100A8/S100A9 alarmins prevent the expansion of a specific inflammatory monocyte population promoting septic shock.
Heinemann AS, Pirr S, Fehlhaber B, Mellinger L, Burgmann J, Busse M, Ginzel M, Friesenhagen J, von Köckritz-Blickwede M, Ulas T, von Kaisenberg CS, Roth J, Vogl T, Viemann D. Heinemann AS, et al. Among authors: pirr s. FASEB J. 2017 Mar;31(3):1153-1164. doi: 10.1096/fj.201601083R. Epub 2016 Dec 19. FASEB J. 2017. PMID: 27993995
Our data suggest that a specific population of inflammatory monocytes promotes fatal courses of sepsis in neonates if its expansion is not regulated by S100A8/S100A9 alarmins.-Heinemann, A. S., Pirr, S., Fehlhaber, B., Mellinger, L., Burgmann, J., Busse, M., …
Our data suggest that a specific population of inflammatory monocytes promotes fatal courses of sepsis in neonates if its expansion is not r …
S100-alarmin-induced innate immune programming protects newborn infants from sepsis.
Ulas T, Pirr S, Fehlhaber B, Bickes MS, Loof TG, Vogl T, Mellinger L, Heinemann AS, Burgmann J, Schöning J, Schreek S, Pfeifer S, Reuner F, Völlger L, Stanulla M, von Köckritz-Blickwede M, Glander S, Barczyk-Kahlert K, von Kaisenberg CS, Friesenhagen J, Fischer-Riepe L, Zenker S, Schultze JL, Roth J, Viemann D. Ulas T, et al. Among authors: pirr s. Nat Immunol. 2017 Jun;18(6):622-632. doi: 10.1038/ni.3745. Epub 2017 May 1. Nat Immunol. 2017. PMID: 28459433
Corrigendum: S100-alarmin-induced innate immune programming protects newborn infants from sepsis.
Ulas T, Pirr S, Fehlhaber B, Bickes MS, Loof TG, Vogl T, Mellinger L, Heinemann AS, Burgmann J, Schöning J, Schreek S, Pfeifer S, Reuner F, Völlger L, Stanulla M, von Köckritz-Blickwede M, Glander S, Barczyk-Kahlert K, von Kaisenberg CS, Friesenhagen J, Fischer-Riepe L, Zenker S, Schultze JL, Roth J, Viemann D. Ulas T, et al. Among authors: pirr s. Nat Immunol. 2017 Sep 19;18(10):1173. doi: 10.1038/ni1017-1173b. Nat Immunol. 2017. PMID: 28926540 No abstract available.
Constitutive TNF-α signaling in neonates is essential for the development of tissue-resident leukocyte profiles at barrier sites.
Bickes MS, Pirr S, Heinemann AS, Fehlhaber B, Halle S, Völlger L, Willers M, Richter M, Böhne C, Albrecht M, Langer M, Pfeifer S, Jonigk D, Vieten G, Ure B, von Kaisenberg C, Förster R, von Köckritz-Blickwede M, Hansen G, Viemann D. Bickes MS, et al. Among authors: pirr s. FASEB J. 2019 Oct;33(10):10633-10647. doi: 10.1096/fj.201900796R. Epub 2019 Jun 29. FASEB J. 2019. PMID: 31262195
Collectively, these data suggest that constitutive TNF-alpha-mediated sterile endothelial activation in newborn infants contributes to the increased risk of developing SIRS but is needed to ensure the postnatal recruitment of leukocytes to organs and interfaces.-Bickes, M. S …
Collectively, these data suggest that constitutive TNF-alpha-mediated sterile endothelial activation in newborn infants contributes to the i …
Efficacy of Bifidobacterium longum, B. infantis and Lactobacillus acidophilus probiotics to prevent gut dysbiosis in preterm infants of 28+0-32+6 weeks of gestation: a randomised, placebo-controlled, double-blind, multicentre trial: the PRIMAL Clinical Study protocol.
Marißen J, Haiß A, Meyer C, Van Rossum T, Bünte LM, Frommhold D, Gille C, Goedicke-Fritz S, Göpel W, Hudalla H, Pagel J, Pirr S, Siller B, Viemann D, Vens M, König I, Herting E, Zemlin M, Gehring S, Bork P, Henneke P, Härtel C; PRIMAL consortium. Marißen J, et al. Among authors: pirr s. BMJ Open. 2019 Nov 21;9(11):e032617. doi: 10.1136/bmjopen-2019-032617. BMJ Open. 2019. PMID: 31753895 Free PMC article.
Lactobacillus Acidophilus/Bifidobacterium Infantis Probiotics Are Beneficial to Extremely Low Gestational Age Infants Fed Human Milk.
Fortmann I, Marißen J, Siller B, Spiegler J, Humberg A, Hanke K, Faust K, Pagel J, Eyvazzadeh L, Brenner K, Roll C, Pirr S, Viemann D, Stavropoulou D, Henneke P, Tröger B, Körner T, Stein A, Derouet C, Zemlin M, Wieg C, Rupp J, Herting E, Göpel W, Härtel C. Fortmann I, et al. Among authors: pirr s. Nutrients. 2020 Mar 22;12(3):850. doi: 10.3390/nu12030850. Nutrients. 2020. PMID: 32235769 Free PMC article.
Microbial exposure drives polyclonal expansion of innate γδ T cells immediately after birth.
Ravens S, Fichtner AS, Willers M, Torkornoo D, Pirr S, Schöning J, Deseke M, Sandrock I, Bubke A, Wilharm A, Dodoo D, Egyir B, Flanagan KL, Steinbrück L, Dickinson P, Ghazal P, Adu B, Viemann D, Prinz I. Ravens S, et al. Among authors: pirr s. Proc Natl Acad Sci U S A. 2020 Aug 4;117(31):18649-18660. doi: 10.1073/pnas.1922588117. Epub 2020 Jul 20. Proc Natl Acad Sci U S A. 2020. PMID: 32690687 Free PMC article.
30 results