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Structure and dynamics of the active Gs-coupled human secretin receptor.
Dong M, Deganutti G, Piper SJ, Liang YL, Khoshouei M, Belousoff MJ, Harikumar KG, Reynolds CA, Glukhova A, Furness SGB, Christopoulos A, Danev R, Wootten D, Sexton PM, Miller LJ. Dong M, et al. Among authors: piper sj. Nat Commun. 2020 Aug 18;11(1):4137. doi: 10.1038/s41467-020-17791-4. Nat Commun. 2020. PMID: 32811827 Free PMC article.
Structure and dynamics of the CGRP receptor in apo and peptide-bound forms.
Josephs TM, Belousoff MJ, Liang YL, Piper SJ, Cao J, Garama DJ, Leach K, Gregory KJ, Christopoulos A, Hay DL, Danev R, Wootten D, Sexton PM. Josephs TM, et al. Among authors: piper sj. Science. 2021 Apr 9;372(6538):eabf7258. doi: 10.1126/science.abf7258. Epub 2021 Feb 18. Science. 2021. PMID: 33602864
Structures of the human cholecystokinin 1 (CCK1) receptor bound to Gs and Gq mimetic proteins provide insight into mechanisms of G protein selectivity.
Mobbs JI, Belousoff MJ, Harikumar KG, Piper SJ, Xu X, Furness SGB, Venugopal H, Christopoulos A, Danev R, Wootten D, Thal DM, Miller LJ, Sexton PM. Mobbs JI, et al. Among authors: piper sj. PLoS Biol. 2021 Jun 4;19(6):e3001295. doi: 10.1371/journal.pbio.3001295. eCollection 2021 Jun. PLoS Biol. 2021. PMID: 34086670 Free PMC article.
Understanding VPAC receptor family peptide binding and selectivity.
Piper SJ, Deganutti G, Lu J, Zhao P, Liang YL, Lu Y, Fletcher MM, Hossain MA, Christopoulos A, Reynolds CA, Danev R, Sexton PM, Wootten D. Piper SJ, et al. Nat Commun. 2022 Nov 16;13(1):7013. doi: 10.1038/s41467-022-34629-3. Nat Commun. 2022. PMID: 36385145 Free PMC article.
19 results