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The Magic Methyl and Its Tricks in Drug Discovery and Development.
Pharmaceuticals (Basel). 2023 Aug 15;16(8):1157. doi: 10.3390/ph16081157.
Pharmaceuticals (Basel). 2023.
PMID: 37631072
Free PMC article.
Review.
Methyl Effect on the Metabolism, Chemical Stability, and Permeability Profile of Bioactive N-Sulfonylhydrazones.
Guedes JS, Carneiro TR, Pinheiro PSM, Fraga CAM, Sant Anna CMR, Barreiro EJ, Lima LM.
Guedes JS, et al. Among authors: pinheiro psm.
ACS Omega. 2022 Oct 19;7(43):38752-38765. doi: 10.1021/acsomega.2c04368. eCollection 2022 Nov 1.
ACS Omega. 2022.
PMID: 36340078
Free PMC article.
Item in Clipboard
Multitarget Inhibition of Histone Deacetylase (HDAC) and Phosphatidylinositol-3-kinase (PI3K): Current and Future Prospects.
Rodrigues DA, Pinheiro PSM, Fraga CAM.
Rodrigues DA, et al. Among authors: pinheiro psm.
ChemMedChem. 2021 Feb 4;16(3):448-457. doi: 10.1002/cmdc.202000643. Epub 2020 Nov 6.
ChemMedChem. 2021.
PMID: 33049098
Review.
Item in Clipboard
Histone deacetylases as targets for the treatment of neurodegenerative disorders: Challenges and future opportunities.
Rodrigues DA, Pinheiro PSM, Sagrillo FS, Bolognesi ML, Fraga CAM.
Rodrigues DA, et al. Among authors: pinheiro psm.
Med Res Rev. 2020 Nov;40(6):2177-2211. doi: 10.1002/med.21701. Epub 2020 Jun 26.
Med Res Rev. 2020.
PMID: 32588916
Review.
Item in Clipboard
Design, Synthesis, Experimental and Theoretical Characterization of a New Multitarget 2-Thienyl-N-Acylhydrazone Derivative.
Bastos ITS, Pinheiro PSM, Costa FN, Rocha MD, Sant'Anna CMR, Braz D, Souza ET, Martins MA, Barreiro EJ, Ferreira FF, Barroso RC, Fraga CAM.
Bastos ITS, et al. Among authors: pinheiro psm.
Pharmaceuticals (Basel). 2018 Nov 1;11(4):119. doi: 10.3390/ph11040119.
Pharmaceuticals (Basel). 2018.
PMID: 30388818
Free PMC article.
Item in Clipboard
N-Acylhydrazones as drugs.
Thota S, Rodrigues DA, Pinheiro PSM, Lima LM, Fraga CAM, Barreiro EJ.
Thota S, et al. Among authors: pinheiro psm.
Bioorg Med Chem Lett. 2018 Sep 15;28(17):2797-2806. doi: 10.1016/j.bmcl.2018.07.015. Epub 2018 Jul 9.
Bioorg Med Chem Lett. 2018.
PMID: 30006065
Review.
Item in Clipboard
An Unusual Intramolecular Halogen Bond Guides Conformational Selection.
Tesch R, Becker C, Müller MP, Beck ME, Quambusch L, Getlik M, Lategahn J, Uhlenbrock N, Costa FN, Polêto MD, Pinheiro PSM, Rodrigues DA, Sant'Anna CMR, Ferreira FF, Verli H, Fraga CAM, Rauh D.
Tesch R, et al. Among authors: pinheiro psm.
Angew Chem Int Ed Engl. 2018 Jul 26;57(31):9970-9975. doi: 10.1002/anie.201804917. Epub 2018 Jul 9.
Angew Chem Int Ed Engl. 2018.
PMID: 29873877
Item in Clipboard
Structural basis for the agonist action at free fatty acid receptor 1 (FFA1R or GPR40).
Rodrigues DA, Pinheiro PSM, Ferreira TTDSC, Thota S, Fraga CAM.
Rodrigues DA, et al. Among authors: pinheiro psm.
Chem Biol Drug Des. 2018 Mar;91(3):668-680. doi: 10.1111/cbdd.13131. Epub 2017 Nov 16.
Chem Biol Drug Des. 2018.
PMID: 29068547
Review.
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