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PNC-27, a Chimeric p53-Penetratin Peptide Binds to HDM-2 in a p53 Peptide-like Structure, Induces Selective Membrane-Pore Formation and Leads to Cancer Cell Lysis.
Sarafraz-Yazdi E, Mumin S, Cheung D, Fridman D, Lin B, Wong L, Rosal R, Rudolph R, Frenkel M, Thadi A, Morano WF, Bowne WB, Pincus MR, Michl J. Sarafraz-Yazdi E, et al. Among authors: pincus mr. Biomedicines. 2022 Apr 20;10(5):945. doi: 10.3390/biomedicines10050945. Biomedicines. 2022. PMID: 35625682 Free PMC article.
The penetratin sequence in the anticancer PNC-28 peptide causes tumor cell necrosis rather than apoptosis of human pancreatic cancer cells.
Bowne WB, Sookraj KA, Vishnevetsky M, Adler V, Sarafraz-Yazdi E, Lou S, Koenke J, Shteyler V, Ikram K, Harding M, Bluth MH, Ng M, Brandt-Rauf PW, Hannan R, Bradu S, Zenilman ME, Michl J, Pincus MR. Bowne WB, et al. Among authors: pincus mr. Ann Surg Oncol. 2008 Dec;15(12):3588-600. doi: 10.1245/s10434-008-0147-0. Epub 2008 Oct 18. Ann Surg Oncol. 2008. PMID: 18931881
Anticancer peptide PNC-27 adopts an HDM-2-binding conformation and kills cancer cells by binding to HDM-2 in their membranes.
Sarafraz-Yazdi E, Bowne WB, Adler V, Sookraj KA, Wu V, Shteyler V, Patel H, Oxbury W, Brandt-Rauf P, Zenilman ME, Michl J, Pincus MR. Sarafraz-Yazdi E, et al. Among authors: pincus mr. Proc Natl Acad Sci U S A. 2010 Feb 2;107(5):1918-23. doi: 10.1073/pnas.0909364107. Epub 2010 Jan 11. Proc Natl Acad Sci U S A. 2010. PMID: 20080680 Free PMC article.
The anti-cancer peptide, PNC-27, induces tumor cell necrosis of a poorly differentiated non-solid tissue human leukemia cell line that depends on expression of HDM-2 in the plasma membrane of these cells.
Davitt K, Babcock BD, Fenelus M, Poon CK, Sarkar A, Trivigno V, Zolkind PA, Matthew SM, Grin'kina N, Orynbayeva Z, Shaikh MF, Adler V, Michl J, Sarafraz-Yazdi E, Pincus MR, Bowne WB. Davitt K, et al. Among authors: pincus mr. Ann Clin Lab Sci. 2014 Summer;44(3):241-8. Ann Clin Lab Sci. 2014. PMID: 25117093
Emerging Role of MDM2 as Target for Anti-Cancer Therapy: A Review.
Shaikh MF, Morano WF, Lee J, Gleeson E, Babcock BD, Michl J, Sarafraz-Yazdi E, Pincus MR, Bowne WB. Shaikh MF, et al. Among authors: pincus mr. Ann Clin Lab Sci. 2016 Dec;46(6):627-634. Ann Clin Lab Sci. 2016. PMID: 27993876 Review.
205 results