Pikul S - Search Results

1

The matrix metalloproteinase inhibitor marimastat inhibits seizures in a model of kainic acid-induced status epilepticus.

Pijet B, Konopka A, Rejmak E, Stefaniuk M, Khomiak D, Bulska E, Pikul S, Kaczmarek L. Pijet B, et al. Among authors: pikul s. Sci Rep. 2020 Dec 4;10(1):21314. doi: 10.1038/s41598-020-78341-y. Sci Rep. 2020. PMID: 33277582 Free PMC article.

2

Design, synthesis, and biological evaluation of matrix metalloproteinase inhibitors derived from a modified proline scaffold.

Cheng M, De B, Almstead NG, Pikul S, Dowty ME, Dietsch CR, Dunaway CM, Gu F, Hsieh LC, Janusz MJ, Taiwo YO, Natchus MG, Hudlicky T, Mandel M. Cheng M, et al. Among authors: pikul s. J Med Chem. 1999 Dec 30;42(26):5426-36. doi: 10.1021/jm9904699. J Med Chem. 1999. PMID: 10639284

3

Comparison of the pharmacology of hydroxamate- and carboxylate-based matrix metalloproteinase inhibitors (MMPIs) for the treatment of osteoarthritis.

Janusz MJ, Hookfin EB, Brown KK, Hsieh LC, Heitmeyer SA, Taiwo YO, Natchus MG, Pikul S, Almstead NG, De B, Peng SX, Baker TR, Patel V. Janusz MJ, et al. Among authors: pikul s. Inflamm Res. 2006 Feb;55(2):60-5. doi: 10.1007/s00011-005-0014-4. Inflamm Res. 2006. PMID: 16612565

4

A New Inhibitor of Tubulin Polymerization Kills Multiple Cancer Cell Types and Reveals p21-Mediated Mechanism Determining Cell Death after Mitotic Catastrophe.

Zdioruk M, Want A, Mietelska-Porowska A, Laskowska-Kaszub K, Wojsiat J, Klejman A, Użarowska E, Koza P, Olejniczak S, Pikul S, Konopka W, Golab J, Wojda U. Zdioruk M, et al. Among authors: pikul s. Cancers (Basel). 2020 Aug 4;12(8):2161. doi: 10.3390/cancers12082161. Cancers (Basel). 2020. PMID: 32759730 Free PMC article.

5

Discovery of potent, achiral matrix metalloproteinase inhibitors.

Pikul S, McDow Dunham KL, Almstead NG, De B, Natchus MG, Anastasio MV, McPhail SJ, Snider CE, Taiwo YO, Rydel T, Dunaway CM, Gu F, Mieling GE. Pikul S, et al. J Med Chem. 1998 Sep 10;41(19):3568-71. doi: 10.1021/jm980253r. J Med Chem. 1998. PMID: 9733482 No abstract available.

6

Design and synthesis of conformationally-constrained MMP inhibitors.

Natchus MG, Cheng M, Wahl CT, Pikul S, Almstead NG, Bradley RS, Taiwo YO, Mieling GE, Dunaway CM, Snider CE, McIver JM, Barnett BL, McPhail SJ, Anastasio MB, De B. Natchus MG, et al. Among authors: pikul s. Bioorg Med Chem Lett. 1998 Aug 18;8(16):2077-80. doi: 10.1016/s0960-894x(98)00370-9. Bioorg Med Chem Lett. 1998. PMID: 9873489

7

Design and synthesis of phosphinamide-based hydroxamic acids as inhibitors of matrix metalloproteinases.

Pikul S, McDow Dunham KL, Almstead NG, De B, Natchus MG, Anastasio MV, McPhail SJ, Snider CE, Taiwo YO, Chen L, Dunaway CM, Gu F, Mieling GE. Pikul S, et al. J Med Chem. 1999 Jan 14;42(1):87-94. doi: 10.1021/jm980142s. J Med Chem. 1999. PMID: 9888835

8

Design, synthesis, and biological evaluation of potent thiazine- and thiazepine-based matrix metalloproteinase inhibitors.

Almstead NG, Bradley RS, Pikul S, De B, Natchus MG, Taiwo YO, Gu F, Williams LE, Hynd BA, Janusz MJ, Dunaway CM, Mieling GE. Almstead NG, et al. Among authors: pikul s. J Med Chem. 1999 Nov 4;42(22):4547-62. doi: 10.1021/jm990330y. J Med Chem. 1999. PMID: 10579818

9

Design and synthesis of piperazine-based matrix metalloproteinase inhibitors.

Cheng M, De B, Pikul S, Almstead NG, Natchus MG, Anastasio MV, McPhail SJ, Snider CE, Taiwo YO, Chen L, Dunaway CM, Gu F, Dowty ME, Mieling GE, Janusz MJ, Wang-Weigand S. Cheng M, et al. Among authors: pikul s. J Med Chem. 2000 Feb 10;43(3):369-80. doi: 10.1021/jm990366q. J Med Chem. 2000. PMID: 10669564

10

Development of new carboxylic acid-based MMP inhibitors derived from functionalized propargylglycines.

Natchus MG, Bookland RG, Laufersweiler MJ, Pikul S, Almstead NG, De B, Janusz MJ, Hsieh LC, Gu F, Pokross ME, Patel VS, Garver SM, Peng SX, Branch TM, King SL, Baker TR, Foltz DJ, Mieling GE. Natchus MG, et al. Among authors: pikul s. J Med Chem. 2001 Mar 29;44(7):1060-71. doi: 10.1021/jm000477l. J Med Chem. 2001. PMID: 11297453

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