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Multiple copies of the oxytetracycline gene cluster in selected Streptomyces rimosus strains can provide significantly increased titers.
Microb Cell Fact. 2021 Feb 17;20(1):47. doi: 10.1186/s12934-021-01522-5.
Microb Cell Fact. 2021.
PMID: 33596911
Free PMC article.
Heterologous expression of the atypical tetracycline chelocardin reveals the full set of genes required for its biosynthesis.
Lukežič T, Pikl Š, Zaburannyi N, Remškar M, Petković H, Müller R.
Lukežič T, et al. Among authors: pikl s.
Microb Cell Fact. 2020 Dec 19;19(1):230. doi: 10.1186/s12934-020-01495-x.
Microb Cell Fact. 2020.
PMID: 33341113
Free PMC article.
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Molecular Biology Methods in Streptomyces rimosus, a Producer of Oxytetracycline.
Slemc L, Pikl Š, Petković H, Avbelj M.
Slemc L, et al. Among authors: pikl s.
Methods Mol Biol. 2021;2296:303-330. doi: 10.1007/978-1-0716-1358-0_18.
Methods Mol Biol. 2021.
PMID: 33977456
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Engineering Atypical Tetracycline Formation in Amycolatopsis sulphurea for the Production of Modified Chelocardin Antibiotics.
Lukežič T, Fayad AA, Bader C, Harmrolfs K, Bartuli J, Groß S, Lešnik U, Hennessen F, Herrmann J, Pikl Š, Petković H, Müller R.
Lukežič T, et al. Among authors: pikl s.
ACS Chem Biol. 2019 Mar 15;14(3):468-477. doi: 10.1021/acschembio.8b01125. Epub 2019 Feb 12.
ACS Chem Biol. 2019.
PMID: 30747520
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