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Beyond Retigabine: Design, Synthesis, and Pharmacological Characterization of a Potent and Chemically Stable Neuronal Kv7 Channel Activator with Anticonvulsant Activity.
Musella S, Carotenuto L, Iraci N, Baroli G, Ciaglia T, Nappi P, Basilicata MG, Salviati E, Barrese V, Vestuto V, Pignataro G, Pepe G, Sommella E, Di Sarno V, Manfra M, Campiglia P, Gomez-Monterrey I, Bertamino A, Taglialatela M, Ostacolo C, Miceli F. Musella S, et al. Among authors: pignataro g. J Med Chem. 2022 Aug 25;65(16):11340-11364. doi: 10.1021/acs.jmedchem.2c00911. Epub 2022 Aug 16. J Med Chem. 2022. PMID: 35972998 Free PMC article.
Neurobiology of coronaviruses: Potential relevance for COVID-19.
Cataldi M, Pignataro G, Taglialatela M. Cataldi M, et al. Among authors: pignataro g. Neurobiol Dis. 2020 Sep;143:105007. doi: 10.1016/j.nbd.2020.105007. Epub 2020 Jul 2. Neurobiol Dis. 2020. PMID: 32622086 Free PMC article. Review.
Synthesis and Characterization of Novel Mono- and Bis-Guanyl Hydrazones as Potent and Selective ASIC1 Inhibitors Able to Reduce Brain Ischemic Insult.
Gornati D, Ciccone R, Vinciguerra A, Ippati S, Pannaccione A, Petrozziello T, Pizzi E, Hassan A, Colombo E, Barbini S, Milani M, Caccavone C, Randazzo P, Muzio L, Annunziato L, Menegon A, Secondo A, Mastrangelo E, Pignataro G, Seneci P. Gornati D, et al. Among authors: pignataro g. J Med Chem. 2021 Jun 24;64(12):8333-8353. doi: 10.1021/acs.jmedchem.1c00305. Epub 2021 Jun 7. J Med Chem. 2021. PMID: 34097384
New Insights into the Structure-Activity Relationship and Neuroprotective Profile of Benzodiazepinone Derivatives of Neurounina-1 as Modulators of the Na+/Ca2+ Exchanger Isoforms.
Magli E, Fattorusso C, Persico M, Corvino A, Esposito G, Fiorino F, Luciano P, Perissutti E, Santagada V, Severino B, Tedeschi V, Pannaccione A, Pignataro G, Caliendo G, Annunziato L, Secondo A, Frecentese F. Magli E, et al. Among authors: pignataro g. J Med Chem. 2021 Dec 23;64(24):17901-17919. doi: 10.1021/acs.jmedchem.1c01212. Epub 2021 Nov 30. J Med Chem. 2021. PMID: 34845907 Free PMC article.
Pharmacological characterization of the newly synthesized 5-amino-N-butyl-2-(4-ethoxyphenoxy)-benzamide hydrochloride (BED) as a potent NCX3 inhibitor that worsens anoxic injury in cortical neurons, organotypic hippocampal cultures, and ischemic brain.
Secondo A, Pignataro G, Ambrosino P, Pannaccione A, Molinaro P, Boscia F, Cantile M, Cuomo O, Esposito A, Sisalli MJ, Scorziello A, Guida N, Anzilotti S, Fiorino F, Severino B, Santagada V, Caliendo G, Di Renzo G, Annunziato L. Secondo A, et al. Among authors: pignataro g. ACS Chem Neurosci. 2015 Aug 19;6(8):1361-70. doi: 10.1021/acschemneuro.5b00043. Epub 2015 May 19. ACS Chem Neurosci. 2015. PMID: 25942323
HDAC4 and HDAC5 form a complex with DREAM that epigenetically down-regulates NCX3 gene and its pharmacological inhibition reduces neuronal stroke damage.
Formisano L, Laudati G, Guida N, Mascolo L, Serani A, Cuomo O, Cantile M, Boscia F, Molinaro P, Anzilotti S, Pizzorusso V, Di Renzo G, Pignataro G, Annunziato L. Formisano L, et al. Among authors: pignataro g. J Cereb Blood Flow Metab. 2020 Oct;40(10):2081-2097. doi: 10.1177/0271678X19884742. Epub 2019 Nov 7. J Cereb Blood Flow Metab. 2020. PMID: 31696766 Free PMC article.
192 results