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Pro-inflammatory cytokine blockade attenuates myeloid expansion in a murine model of rheumatoid arthritis.
Hernandez G, Mills TS, Rabe JL, Chavez JS, Kuldanek S, Kirkpatrick G, Noetzli L, Jubair WK, Zanche M, Myers JR, Stevens BM, Fleenor CJ, Adane B, Dinarello CA, Ashton J, Jordan CT, Di Paola J, Hagman JR, Holers VM, Kuhn KA, Pietras EM. Hernandez G, et al. Among authors: pietras em. Haematologica. 2020 Mar;105(3):585-597. doi: 10.3324/haematol.2018.197210. Epub 2019 May 17. Haematologica. 2020. PMID: 31101752 Free PMC article.
Zinc Finger Protein 521 Regulates Early Hematopoiesis through Cell-Extrinsic Mechanisms in the Bone Marrow Microenvironment.
Fleenor CJ, Arends T, Lei H, Åhsberg J, Okuyama K, Kuruvilla J, Cristobal S, Rabe JL, Pandey A, Danhorn T, Straign D, Espinosa JM, Warming S, Pietras EM, Sigvardsson M, Hagman JR. Fleenor CJ, et al. Among authors: pietras em. Mol Cell Biol. 2018 Aug 15;38(17):e00603-17. doi: 10.1128/MCB.00603-17. Print 2018 Sep 1. Mol Cell Biol. 2018. PMID: 29915154 Free PMC article.
PI3 kinase alpha and delta promote hematopoietic stem cell activation.
Hemmati S, Sinclair T, Tong M, Bartholdy B, Okabe RO, Ames K, Ostrodka L, Haque T, Kaur I, Mills TS, Agarwal A, Pietras EM, Zhao JJ, Roberts TM, Gritsman K. Hemmati S, et al. Among authors: pietras em. JCI Insight. 2019 May 23;5(13):e125832. doi: 10.1172/jci.insight.125832. JCI Insight. 2019. PMID: 31120863 Free PMC article.
ETV6 germline mutations cause HDAC3/NCOR2 mislocalization and upregulation of interferon response genes.
Fisher MH, Kirkpatrick GD, Stevens B, Jones C, Callaghan M, Rajpurkar M, Fulbright J, Cooper MA, Rowley J, Porter CC, Gutierrez-Hartmann A, Jones K, Jordan C, Pietras EM, Di Paola J. Fisher MH, et al. Among authors: pietras em. JCI Insight. 2020 Sep 17;5(18):e140332. doi: 10.1172/jci.insight.140332. JCI Insight. 2020. PMID: 32841218 Free PMC article.
Targeting tumor-derived NLRP3 reduces melanoma progression by limiting MDSCs expansion.
Tengesdal IW, Menon DR, Osborne DG, Neff CP, Powers NE, Gamboni F, Mauro AG, D'Alessandro A, Stefanoni D, Henen MA, Mills TS, De Graaf DM, Azam T, Vogeli B, Palmer BE, Pietras EM, DeGregori J, Tan AC, Joosten LAB, Fujita M, Dinarello CA, Marchetti C. Tengesdal IW, et al. Among authors: pietras em. Proc Natl Acad Sci U S A. 2021 Mar 9;118(10):e2000915118. doi: 10.1073/pnas.2000915118. Proc Natl Acad Sci U S A. 2021. PMID: 33649199 Free PMC article.
The anti-inflammatory cytokine interleukin-37 is an inhibitor of trained immunity.
Cavalli G, Tengesdal IW, Gresnigt M, Nemkov T, Arts RJW, Domínguez-Andrés J, Molteni R, Stefanoni D, Cantoni E, Cassina L, Giugliano S, Schraa K, Mills TS, Pietras EM, Eisenmensser EZ, Dagna L, Boletta A, D'Alessandro A, Joosten LAB, Netea MG, Dinarello CA. Cavalli G, et al. Among authors: pietras em. Cell Rep. 2021 Apr 6;35(1):108955. doi: 10.1016/j.celrep.2021.108955. Cell Rep. 2021. PMID: 33826894 Free article.
66 results