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Trimethylangelicin reduces IL-8 transcription and potentiates CFTR function.
Tamanini A, Borgatti M, Finotti A, Piccagli L, Bezzerri V, Favia M, Guerra L, Lampronti I, Bianchi N, Dall'Acqua F, Vedaldi D, Salvador A, Fabbri E, Mancini I, Nicolis E, Casavola V, Cabrini G, Gambari R. Tamanini A, et al. Among authors: piccagli l. Am J Physiol Lung Cell Mol Physiol. 2011 Mar;300(3):L380-90. doi: 10.1152/ajplung.00129.2010. Epub 2010 Dec 10. Am J Physiol Lung Cell Mol Physiol. 2011. PMID: 21148790 Free article.
Targeting transcription factor activity as a strategy to inhibit pro-inflammatory genes involved in cystic fibrosis: decoy oligonucleotides and low-molecular weight compounds.
Cabrini G, Bezzerri V, Mancini I, Nicolis E, Dechecchi MC, Tamanini A, Lampronti I, Piccagli L, Bianchi N, Borgatti M, Gambari R. Cabrini G, et al. Among authors: piccagli l. Curr Med Chem. 2010;17(35):4392-404. doi: 10.2174/092986710793361243. Curr Med Chem. 2010. PMID: 20939807 Review.
Docking of molecules identified in bioactive medicinal plants extracts into the p50 NF-kappaB transcription factor: correlation with inhibition of NF-kappaB/DNA interactions and inhibitory effects on IL-8 gene expression.
Piccagli L, Fabbri E, Borgatti M, Bezzerri V, Mancini I, Nicolis E, Dechecchi MC, Lampronti I, Cabrini G, Gambari R. Piccagli L, et al. BMC Struct Biol. 2008 Sep 3;8:38. doi: 10.1186/1472-6807-8-38. BMC Struct Biol. 2008. PMID: 18768082 Free PMC article.
Virtual screening against nuclear factor κB (NF-κB) of a focus library: Identification of bioactive furocoumarin derivatives inhibiting NF-κB dependent biological functions involved in cystic fibrosis.
Piccagli L, Borgatti M, Nicolis E, Bianchi N, Mancini I, Lampronti I, Vevaldi D, Dall'Acqua F, Cabrini G, Gambari R. Piccagli L, et al. Bioorg Med Chem. 2010 Dec 1;18(23):8341-9. doi: 10.1016/j.bmc.2010.09.063. Epub 2010 Oct 1. Bioorg Med Chem. 2010. PMID: 20980154
Corilagin is a potent inhibitor of NF-kappaB activity and downregulates TNF-alpha induced expression of IL-8 gene in cystic fibrosis IB3-1 cells.
Gambari R, Borgatti M, Lampronti I, Fabbri E, Brognara E, Bianchi N, Piccagli L, Yuen MC, Kan CW, Hau DK, Fong WF, Wong WY, Wong RS, Chui CH. Gambari R, et al. Among authors: piccagli l. Int Immunopharmacol. 2012 Jul;13(3):308-15. doi: 10.1016/j.intimp.2012.04.010. Epub 2012 May 4. Int Immunopharmacol. 2012. PMID: 22561123
Heterocyclic and phenyl double-bond-locked combretastatin analogues possessing potent apoptosis-inducing activity in HL60 and in MDR cell lines.
Simoni D, Grisolia G, Giannini G, Roberti M, Rondanin R, Piccagli L, Baruchello R, Rossi M, Romagnoli R, Invidiata FP, Grimaudo S, Jung MK, Hamel E, Gebbia N, Crosta L, Abbadessa V, Di Cristina A, Dusonchet L, Meli M, Tolomeo M. Simoni D, et al. Among authors: piccagli l. J Med Chem. 2005 Feb 10;48(3):723-36. doi: 10.1021/jm049622b. J Med Chem. 2005. PMID: 15689156
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