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Page 1
Design of protein-binding proteins from the target structure alone.
Cao L, Coventry B, Goreshnik I, Huang B, Sheffler W, Park JS, Jude KM, Marković I, Kadam RU, Verschueren KHG, Verstraete K, Walsh STR, Bennett N, Phal A, Yang A, Kozodoy L, DeWitt M, Picton L, Miller L, Strauch EM, DeBouver ND, Pires A, Bera AK, Halabiya S, Hammerson B, Yang W, Bernard S, Stewart L, Wilson IA, Ruohola-Baker H, Schlessinger J, Lee S, Savvides SN, Garcia KC, Baker D. Cao L, et al. Among authors: phal a. Nature. 2022 May;605(7910):551-560. doi: 10.1038/s41586-022-04654-9. Epub 2022 Mar 24. Nature. 2022. PMID: 35332283 Free PMC article.
dCas9 fusion to computer-designed PRC2 inhibitor reveals functional TATA box in distal promoter region.
Levy S, Somasundaram L, Raj IX, Ic-Mex D, Phal A, Schmidt S, Ng WI, Mar D, Decarreau J, Moss N, Alghadeer A, Honkanen H, Sarthy J, Vitanza A, Hawkins RD, Mathieu J, Wang Y, Baker D, Bomsztyk K, Ruohola-Baker H. Levy S, et al. Among authors: phal a. Cell Rep. 2022 Mar 1;38(9):110457. doi: 10.1016/j.celrep.2022.110457. Cell Rep. 2022. PMID: 35235780 Free PMC article.
Next-generation direct reprogramming.
Keshri R, Detraux D, Phal A, McCurdy C, Jhajharia S, Chan TC, Mathieu J, Ruohola-Baker H. Keshri R, et al. Among authors: phal a. Front Cell Dev Biol. 2024 Feb 2;12:1343106. doi: 10.3389/fcell.2024.1343106. eCollection 2024. Front Cell Dev Biol. 2024. PMID: 38371924 Free PMC article. Review.
Single Cell RNA Sequencing Reveals Human Tooth Type Identity and Guides In Vitro hiPSC Derived Odontoblast Differentiation (iOB).
Hanson-Drury S, Patni AP, Lee DL, Alghadeer A, Zhao YT, Ehnes DD, Vo VN, Kim SY, Jithendra D, Phal A, Edman NI, Schlichthaerle T, Baker D, Young JE, Mathieu J, Ruohola-Baker H. Hanson-Drury S, et al. Among authors: phal a. Front Dent Med. 2023;4:10.3389/fdmed.2023.1209503. doi: 10.3389/fdmed.2023.1209503. Epub 2023 Jul 20. Front Dent Med. 2023. PMID: 38259324 Free PMC article.
Single-cell census of human tooth development enables generation of human enamel.
Alghadeer A, Hanson-Drury S, Patni AP, Ehnes DD, Zhao YT, Li Z, Phal A, Vincent T, Lim YC, O'Day D, Spurrell CH, Gogate AA, Zhang H, Devi A, Wang Y, Starita L, Doherty D, Glass IA, Shendure J, Freedman BS, Baker D, Regier MC, Mathieu J, Ruohola-Baker H. Alghadeer A, et al. Among authors: phal a. Dev Cell. 2023 Oct 23;58(20):2163-2180.e9. doi: 10.1016/j.devcel.2023.07.013. Epub 2023 Aug 14. Dev Cell. 2023. PMID: 37582367
Modulation of FGF pathway signaling and vascular differentiation using designed oligomeric assemblies.
Edman NI, Redler RL, Phal A, Schlichthaerle T, Srivatsan SR, Etemadi A, An SJ, Favor A, Ehnes D, Li Z, Praetorius F, Gordon M, Yang W, Coventry B, Hicks DR, Cao L, Bethel N, Heine P, Murray A, Gerben S, Carter L, Miranda M, Negahdari B, Lee S, Trapnell C, Stewart L, Ekiert DC, Schlessinger J, Shendure J, Bhabha G, Ruohola-Baker H, Baker D. Edman NI, et al. Among authors: phal a. bioRxiv [Preprint]. 2023 Mar 15:2023.03.14.532666. doi: 10.1101/2023.03.14.532666. bioRxiv. 2023. PMID: 36993355 Free PMC article. Preprint.