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Targeting Gαi/s Proteins with Peptidyl Nucleotide Exchange Modulators.
ACS Chem Biol. 2022 Feb 18;17(2):463-473. doi: 10.1021/acschembio.1c00929. Epub 2022 Jan 18.
ACS Chem Biol. 2022.
PMID: 35042325
Free PMC article.
Heterotrimeric Gq proteins as therapeutic targets?
Kostenis E, Pfeil EM, Annala S.
Kostenis E, et al. Among authors: pfeil em.
J Biol Chem. 2020 Apr 17;295(16):5206-5215. doi: 10.1074/jbc.REV119.007061. Epub 2020 Mar 2.
J Biol Chem. 2020.
PMID: 32122969
Free PMC article.
Review.
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Direct targeting of Gαq and Gα11 oncoproteins in cancer cells.
Annala S, Feng X, Shridhar N, Eryilmaz F, Patt J, Yang J, Pfeil EM, Cervantes-Villagrana RD, Inoue A, Häberlein F, Slodczyk T, Reher R, Kehraus S, Monteleone S, Schrage R, Heycke N, Rick U, Engel S, Pfeifer A, Kolb P, König G, Bünemann M, Tüting T, Vázquez-Prado J, Gutkind JS, Gaffal E, Kostenis E.
Annala S, et al. Among authors: pfeil em.
Sci Signal. 2019 Mar 19;12(573):eaau5948. doi: 10.1126/scisignal.aau5948.
Sci Signal. 2019.
PMID: 30890659
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Heterotrimeric G Protein Subunit Gαq Is a Master Switch for Gβγ-Mediated Calcium Mobilization by Gi-Coupled GPCRs.
Pfeil EM, Brands J, Merten N, Vögtle T, Vescovo M, Rick U, Albrecht IM, Heycke N, Kawakami K, Ono Y, Ngako Kadji FM, Hiratsuka S, Aoki J, Häberlein F, Matthey M, Garg J, Hennen S, Jobin ML, Seier K, Calebiro D, Pfeifer A, Heinemann A, Wenzel D, König GM, Nieswandt B, Fleischmann BK, Inoue A, Simon K, Kostenis E.
Pfeil EM, et al.
Mol Cell. 2020 Dec 17;80(6):940-954.e6. doi: 10.1016/j.molcel.2020.10.027. Epub 2020 Nov 16.
Mol Cell. 2020.
PMID: 33202251
Free article.
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Label-Free Whole Cell Biosensing for High-Throughput Discovery of Activators and Inhibitors Targeting G Protein-Activated Inwardly Rectifying Potassium Channels.
Krebs KM, Pfeil EM, Simon K, Grundmann M, Häberlein F, Bautista-Aguilera OM, Gütschow M, Weaver CD, Fleischmann BK, Kostenis E.
Krebs KM, et al. Among authors: pfeil em.
ACS Omega. 2018 Nov 30;3(11):14814-14823. doi: 10.1021/acsomega.8b02254. Epub 2018 Nov 5.
ACS Omega. 2018.
PMID: 30555990
Free PMC article.
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An experimental strategy to probe Gq contribution to signal transduction in living cells.
Patt J, Alenfelder J, Pfeil EM, Voss JH, Merten N, Eryilmaz F, Heycke N, Rick U, Inoue A, Kehraus S, Deupi X, Müller CE, König GM, Crüsemann M, Kostenis E.
Patt J, et al. Among authors: pfeil em.
J Biol Chem. 2021 Jan-Jun;296:100472. doi: 10.1016/j.jbc.2021.100472. Epub 2021 Feb 25.
J Biol Chem. 2021.
PMID: 33639168
Free PMC article.
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Ligand-Specific Allosteric Coupling Controls G-Protein-Coupled Receptor Signaling.
Holze J, Bermudez M, Pfeil EM, Kauk M, Bödefeld T, Irmen M, Matera C, Dallanoce C, De Amici M, Holzgrabe U, König GM, Tränkle C, Wolber G, Schrage R, Mohr K, Hoffmann C, Kostenis E, Bock A.
Holze J, et al. Among authors: pfeil em.
ACS Pharmacol Transl Sci. 2020 Sep 2;3(5):859-867. doi: 10.1021/acsptsci.0c00069. eCollection 2020 Oct 9.
ACS Pharmacol Transl Sci. 2020.
PMID: 33073186
Free PMC article.
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