Pey AL - Search Results

1

Natural Small Molecules as Stabilizers and Activators of Cancer-Associated NQO1 Polymorphisms.

Pey AL, Megarity CF, Medina-Carmona E, Timson DJ. Pey AL, et al. Curr Drug Targets. 2016;17(13):1506-14. doi: 10.2174/1389450117666160101121610. Curr Drug Targets. 2016. PMID: 26721407 Review.

2

The metastability of human UDP-galactose 4'-epimerase (GALE) is increased by variants associated with type III galactosemia but decreased by substrate and cofactor binding.

Pey AL, Padín-Gonzalez E, Mesa-Torres N, Timson DJ. Pey AL, et al. Arch Biochem Biophys. 2014 Nov 15;562:103-14. doi: 10.1016/j.abb.2014.07.030. Epub 2014 Aug 19. Arch Biochem Biophys. 2014. PMID: 25150110

3

FAD binding overcomes defects in activity and stability displayed by cancer-associated variants of human NQO1.

Pey AL, Megarity CF, Timson DJ. Pey AL, et al. Biochim Biophys Acta. 2014 Nov;1842(11):2163-73. doi: 10.1016/j.bbadis.2014.08.011. Epub 2014 Aug 29. Biochim Biophys Acta. 2014. PMID: 25179580 Free article.

4

Conformational dynamics is key to understanding loss-of-function of NQO1 cancer-associated polymorphisms and its correction by pharmacological ligands.

Medina-Carmona E, Palomino-Morales RJ, Fuchs JE, Padín-Gonzalez E, Mesa-Torres N, Salido E, Timson DJ, Pey AL. Medina-Carmona E, et al. Among authors: pey al. Sci Rep. 2016 Feb 3;6:20331. doi: 10.1038/srep20331. Sci Rep. 2016. PMID: 26838129 Free PMC article.

5

Galactokinase promiscuity: a question of flexibility?

McAuley M, Kristiansson H, Huang M, Pey AL, Timson DJ. McAuley M, et al. Among authors: pey al. Biochem Soc Trans. 2016 Feb;44(1):116-22. doi: 10.1042/BST20150188. Biochem Soc Trans. 2016. PMID: 26862196 Free article. Review.

6

Erratum: Conformational dynamics is key to understanding loss-of-function of NQO1 cancer-associated polymorphisms and its correction by pharmacological ligands.

Medina-Carmona E, Palomino-Morales RJ, Fuchs JE, Padín-Gonzalez E, Mesa-Torres N, Salido E, Timson DJ, Pey AL. Medina-Carmona E, et al. Among authors: pey al. Sci Rep. 2016 Mar 4;6:21939. doi: 10.1038/srep21939. Sci Rep. 2016. PMID: 26942855 Free PMC article. No abstract available.

7

The chondroitin sulfate/dermatan sulfate 4-O-endosulfatase from marine bacterium Vibrio sp FC509 is a dimeric species: Biophysical characterization of an endosulfatase.

Neira JL, Medina-Carmona E, Hernández-Cifre JG, Montoliu-Gaya L, Cámara-Artigás A, Seffouh I, Gonnet F, Daniel R, Villegas S, de la Torre JG, Pey AL, Li F. Neira JL, et al. Among authors: pey al. Biochimie. 2016 Dec;131:85-95. doi: 10.1016/j.biochi.2016.09.015. Epub 2016 Oct 1. Biochimie. 2016. PMID: 27687161

8

Site-to-site interdomain communication may mediate different loss-of-function mechanisms in a cancer-associated NQO1 polymorphism.

Medina-Carmona E, Neira JL, Salido E, Fuchs JE, Palomino-Morales R, Timson DJ, Pey AL. Medina-Carmona E, et al. Among authors: pey al. Sci Rep. 2017 Mar 14;7:44532. doi: 10.1038/srep44532. Sci Rep. 2017. PMID: 28291250 Free PMC article.

9

A mechanism for cancer-associated inactivation of NQO1 due to P187S and its reactivation by the consensus mutation H80R.

Muñoz IG, Morel B, Medina-Carmona E, Pey AL. Muñoz IG, et al. Among authors: pey al. FEBS Lett. 2017 Sep;591(18):2826-2835. doi: 10.1002/1873-3468.12772. Epub 2017 Aug 20. FEBS Lett. 2017. PMID: 28771686 Free article.

10

Enhanced vulnerability of human proteins towards disease-associated inactivation through divergent evolution.

Medina-Carmona E, Fuchs JE, Gavira JA, Mesa-Torres N, Neira JL, Salido E, Palomino-Morales R, Burgos M, Timson DJ, Pey AL. Medina-Carmona E, et al. Among authors: pey al. Hum Mol Genet. 2017 Sep 15;26(18):3531-3544. doi: 10.1093/hmg/ddx238. Hum Mol Genet. 2017. PMID: 28911204

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