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Oxidative stress-mediated antimalarial activity of plakortin, a natural endoperoxide from the tropical sponge Plakortis simplex.
Skorokhod OA, Davalos-Schafler D, Gallo V, Valente E, Ulliers D, Notarpietro A, Mandili G, Novelli F, Persico M, Taglialatela-Scafati O, Arese P, Schwarzer E. Skorokhod OA, et al. Among authors: persico m. Free Radic Biol Med. 2015 Dec;89:624-37. doi: 10.1016/j.freeradbiomed.2015.10.399. Epub 2015 Oct 13. Free Radic Biol Med. 2015. PMID: 26459031 Free article.
Insight into the mechanism of action of plakortins, simple 1,2-dioxane antimalarials.
Taglialatela-Scafati O, Fattorusso E, Romano A, Scala F, Barone V, Cimino P, Stendardo E, Catalanotti B, Persico M, Fattorusso C. Taglialatela-Scafati O, et al. Among authors: persico m. Org Biomol Chem. 2010 Feb 21;8(4):846-56. doi: 10.1039/b918600j. Epub 2009 Dec 16. Org Biomol Chem. 2010. PMID: 20135043
A new class of antimalarial dioxanes obtained through a simple two-step synthetic approach: rational design and structure-activity relationship studies.
Persico M, Quintavalla A, Rondinelli F, Trombini C, Lombardo M, Fattorusso C, Azzarito V, Taramelli D, Parapini S, Corbett Y, Chianese G, Fattorusso E, Taglialatela-Scafati O. Persico M, et al. J Med Chem. 2011 Dec 22;54(24):8526-40. doi: 10.1021/jm201056j. Epub 2011 Nov 23. J Med Chem. 2011. PMID: 22054038
Clotrimazole scaffold as an innovative pharmacophore towards potent antimalarial agents: design, synthesis, and biological and structure-activity relationship studies.
Gemma S, Campiani G, Butini S, Kukreja G, Coccone SS, Joshi BP, Persico M, Nacci V, Fiorini I, Novellino E, Fattorusso E, Taglialatela-Scafati O, Savini L, Taramelli D, Basilico N, Parapini S, Morace G, Yardley V, Croft S, Coletta M, Marini S, Fattorusso C. Gemma S, et al. Among authors: persico m. J Med Chem. 2008 Mar 13;51(5):1278-94. doi: 10.1021/jm701247k. Epub 2008 Feb 16. J Med Chem. 2008. PMID: 18278860 Free article.
502 results