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Structural conservation of Lassa virus glycoproteins and recognition by neutralizing antibodies.
Perrett HR, Brouwer PJM, Hurtado J, Newby ML, Liu L, Müller-Kräuter H, Müller Aguirre S, Burger JA, Bouhuijs JH, Gibson G, Messmer T, Schieffelin JS, Antanasijevic A, Boons GJ, Strecker T, Crispin M, Sanders RW, Briney B, Ward AB. Perrett HR, et al. Cell Rep. 2023 May 30;42(5):112524. doi: 10.1016/j.celrep.2023.112524. Epub 2023 May 18. Cell Rep. 2023. PMID: 37209096 Free PMC article.
SARS-CoV-2 Infection Depends on Cellular Heparan Sulfate and ACE2.
Clausen TM, Sandoval DR, Spliid CB, Pihl J, Perrett HR, Painter CD, Narayanan A, Majowicz SA, Kwong EM, McVicar RN, Thacker BE, Glass CA, Yang Z, Torres JL, Golden GJ, Bartels PL, Porell RN, Garretson AF, Laubach L, Feldman J, Yin X, Pu Y, Hauser BM, Caradonna TM, Kellman BP, Martino C, Gordts PLSM, Chanda SK, Schmidt AG, Godula K, Leibel SL, Jose J, Corbett KD, Ward AB, Carlin AF, Esko JD. Clausen TM, et al. Among authors: perrett hr. Cell. 2020 Nov 12;183(4):1043-1057.e15. doi: 10.1016/j.cell.2020.09.033. Epub 2020 Sep 14. Cell. 2020. PMID: 32970989 Free PMC article.
Polyclonal antibody responses to HIV Env immunogens resolved using cryoEM.
Antanasijevic A, Sewall LM, Cottrell CA, Carnathan DG, Jimenez LE, Ngo JT, Silverman JB, Groschel B, Georgeson E, Bhiman J, Bastidas R, LaBranche C, Allen JD, Copps J, Perrett HR, Rantalainen K, Cannac F, Yang YR, de la Peña AT, Rocha RF, Berndsen ZT, Baker D, King NP, Sanders RW, Moore JP, Crotty S, Crispin M, Montefiori DC, Burton DR, Schief WR, Silvestri G, Ward AB. Antanasijevic A, et al. Among authors: perrett hr. Nat Commun. 2021 Aug 10;12(1):4817. doi: 10.1038/s41467-021-25087-4. Nat Commun. 2021. PMID: 34376662 Free PMC article.
Lassa virus glycoprotein nanoparticles elicit neutralizing antibody responses and protection.
Brouwer PJM, Antanasijevic A, Ronk AJ, Müller-Kräuter H, Watanabe Y, Claireaux M, Perrett HR, Bijl TPL, Grobben M, Umotoy JC, Schriek AI, Burger JA, Tejjani K, Lloyd NM, Steijaert TH, van Haaren MM, Sliepen K, de Taeye SW, van Gils MJ, Crispin M, Strecker T, Bukreyev A, Ward AB, Sanders RW. Brouwer PJM, et al. Among authors: perrett hr. Cell Host Microbe. 2022 Dec 14;30(12):1759-1772.e12. doi: 10.1016/j.chom.2022.10.018. Epub 2022 Nov 17. Cell Host Microbe. 2022. PMID: 36400021 Free PMC article.
A Lassa virus mRNA vaccine confers protection but does not require neutralizing antibody in a guinea pig model of infection.
Ronk AJ, Lloyd NM, Zhang M, Atyeo C, Perrett HR, Mire CE, Hastie KM, Sanders RW, Brouwer PJM, Saphire EO, Ward AB, Ksiazek TG, Alvarez Moreno JC, Thaker HM, Alter G, Himansu S, Carfi A, Bukreyev A. Ronk AJ, et al. Among authors: perrett hr. Nat Commun. 2023 Sep 12;14(1):5603. doi: 10.1038/s41467-023-41376-6. Nat Commun. 2023. PMID: 37699929 Free PMC article.
Immune memory shapes human polyclonal antibody responses to H2N2 vaccination.
Yang YR, Han J, Perrett HR, Richey ST, Jackson AM, Rodriguez AJ, Gillespie RA, O'Connell S, Raab JE, Cominsky LY, Chopde A, Kanekiyo M, Houser KV, Chen GL, McDermott AB, Andrews SF, Ward AB. Yang YR, et al. Among authors: perrett hr. bioRxiv [Preprint]. 2023 Aug 24:2023.08.23.554525. doi: 10.1101/2023.08.23.554525. bioRxiv. 2023. PMID: 37781590 Free PMC article. Preprint.
Structure and Dynamics Guiding Design of Antibody Therapeutics and Vaccines.
Fernández-Quintero ML, Pomarici ND, Fischer AM, Hoerschinger VJ, Kroell KB, Riccabona JR, Kamenik AS, Loeffler JR, Ferguson JA, Perrett HR, Liedl KR, Han J, Ward AB. Fernández-Quintero ML, et al. Among authors: perrett hr. Antibodies (Basel). 2023 Oct 18;12(4):67. doi: 10.3390/antib12040067. Antibodies (Basel). 2023. PMID: 37873864 Free PMC article. Review.
Defining bottlenecks and opportunities for Lassa virus neutralization by structural profiling of vaccine-induced polyclonal antibody responses.
Brouwer PJM, Perrett HR, Beaumont T, Nijhuis H, Kruijer S, Burger JA, Lee WH, Müller-Kraüter H, Sanders RW, Strecker T, van Gils MJ, Ward AB. Brouwer PJM, et al. Among authors: perrett hr. bioRxiv [Preprint]. 2023 Dec 23:2023.12.21.572918. doi: 10.1101/2023.12.21.572918. bioRxiv. 2023. PMID: 38187682 Free PMC article. Preprint.
Immune memory shapes human polyclonal antibody responses to H2N2 vaccination.
Yang YR, Han J, Perrett HR, Richey ST, Rodriguez AJ, Jackson AM, Gillespie RA, O'Connell S, Raab JE, Cominsky LY, Chopde A, Kanekiyo M, Houser KV, Chen GL, McDermott AB, Andrews SF, Ward AB. Yang YR, et al. Among authors: perrett hr. Cell Rep. 2024 May 7;43(5):114171. doi: 10.1016/j.celrep.2024.114171. Online ahead of print. Cell Rep. 2024. PMID: 38717904
A cornucopia of Shigella phages from the Cornhusker State.
Doore SM, Schrad JR, Perrett HR, Schrad KP, Dean WF, Parent KN. Doore SM, et al. Among authors: perrett hr. Virology. 2019 Dec;538:45-52. doi: 10.1016/j.virol.2019.09.007. Epub 2019 Sep 18. Virology. 2019. PMID: 31569014 Free PMC article.