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Lack of p53 decreases basal oxidative stress levels in the brain through upregulation of thioredoxin-1, biliverdin reductase-A, manganese superoxide dismutase, and nuclear factor kappa-B.
Barone E, Cenini G, Sultana R, Di Domenico F, Fiorini A, Perluigi M, Noel T, Wang C, Mancuso C, St Clair DK, Butterfield DA. Barone E, et al. Among authors: perluigi m. Antioxid Redox Signal. 2012 Jun 15;16(12):1407-20. doi: 10.1089/ars.2011.4124. Epub 2012 Feb 21. Antioxid Redox Signal. 2012. PMID: 22229939 Free PMC article.
Neuropathological role of PI3K/Akt/mTOR axis in Down syndrome brain.
Perluigi M, Pupo G, Tramutola A, Cini C, Coccia R, Barone E, Head E, Butterfield DA, Di Domenico F. Perluigi M, et al. Biochim Biophys Acta. 2014 Jul;1842(7):1144-53. doi: 10.1016/j.bbadis.2014.04.007. Epub 2014 Apr 13. Biochim Biophys Acta. 2014. PMID: 24735980 Free PMC article.
145 results