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Multivalent antigen display on nanoparticle immunogens increases B cell clonotype diversity and neutralization breadth to pneumoviruses.
Ols S, Lenart K, Arcoverde Cerveira R, Miranda MC, Brunette N, Kochmann J, Corcoran M, Skotheim R, Philomin A, Cagigi A, Fiala B, Wrenn S, Marcandalli J, Hellgren F, Thompson EA, Lin A, Gegenfurtner F, Kumar A, Chen M, Phad GE, Graham BS, Perez L, Borst AJ, Karlsson Hedestam GB, Ruckwardt TJ, King NP, Loré K. Ols S, et al. Among authors: perez l. Immunity. 2023 Oct 10;56(10):2425-2441.e14. doi: 10.1016/j.immuni.2023.08.011. Epub 2023 Sep 8. Immunity. 2023. PMID: 37689061 Free article.
Antibody-driven design of a human cytomegalovirus gHgLpUL128L subunit vaccine that selectively elicits potent neutralizing antibodies.
Kabanova A, Perez L, Lilleri D, Marcandalli J, Agatic G, Becattini S, Preite S, Fuschillo D, Percivalle E, Sallusto F, Gerna G, Corti D, Lanzavecchia A. Kabanova A, et al. Among authors: perez l. Proc Natl Acad Sci U S A. 2014 Dec 16;111(50):17965-70. doi: 10.1073/pnas.1415310111. Epub 2014 Dec 1. Proc Natl Acad Sci U S A. 2014. PMID: 25453106 Free PMC article.
Protective monotherapy against lethal Ebola virus infection by a potently neutralizing antibody.
Corti D, Misasi J, Mulangu S, Stanley DA, Kanekiyo M, Wollen S, Ploquin A, Doria-Rose NA, Staupe RP, Bailey M, Shi W, Choe M, Marcus H, Thompson EA, Cagigi A, Silacci C, Fernandez-Rodriguez B, Perez L, Sallusto F, Vanzetta F, Agatic G, Cameroni E, Kisalu N, Gordon I, Ledgerwood JE, Mascola JR, Graham BS, Muyembe-Tamfun JJ, Trefry JC, Lanzavecchia A, Sullivan NJ. Corti D, et al. Among authors: perez l. Science. 2016 Mar 18;351(6279):1339-42. doi: 10.1126/science.aad5224. Epub 2016 Feb 25. Science. 2016. PMID: 26917593
Induction of Potent Neutralizing Antibody Responses by a Designed Protein Nanoparticle Vaccine for Respiratory Syncytial Virus.
Marcandalli J, Fiala B, Ols S, Perotti M, de van der Schueren W, Snijder J, Hodge E, Benhaim M, Ravichandran R, Carter L, Sheffler W, Brunner L, Lawrenz M, Dubois P, Lanzavecchia A, Sallusto F, Lee KK, Veesler D, Correnti CE, Stewart LJ, Baker D, Loré K, Perez L, King NP. Marcandalli J, et al. Among authors: perez l. Cell. 2019 Mar 7;176(6):1420-1431.e17. doi: 10.1016/j.cell.2019.01.046. Cell. 2019. PMID: 30849373 Free PMC article.
HCMV Envelope Glycoprotein Diversity Demystified.
Foglierini M, Marcandalli J, Perez L. Foglierini M, et al. Among authors: perez l. Front Microbiol. 2019 May 15;10:1005. doi: 10.3389/fmicb.2019.01005. eCollection 2019. Front Microbiol. 2019. PMID: 31156572 Free PMC article.
Limited access to antigen drives generation of early B cell memory while restraining the plasmablast response.
Glaros V, Rauschmeier R, Artemov AV, Reinhardt A, Ols S, Emmanouilidi A, Gustafsson C, You Y, Mirabello C, Björklund ÅK, Perez L, King NP, Månsson R, Angeletti D, Loré K, Adameyko I, Busslinger M, Kreslavsky T. Glaros V, et al. Among authors: perez l. Immunity. 2021 Sep 14;54(9):2005-2023.e10. doi: 10.1016/j.immuni.2021.08.017. Immunity. 2021. PMID: 34525339 Free PMC article.
Cross-neutralization of four paramyxoviruses by a human monoclonal antibody.
Corti D, Bianchi S, Vanzetta F, Minola A, Perez L, Agatic G, Guarino B, Silacci C, Marcandalli J, Marsland BJ, Piralla A, Percivalle E, Sallusto F, Baldanti F, Lanzavecchia A. Corti D, et al. Among authors: perez l. Nature. 2013 Sep 19;501(7467):439-43. doi: 10.1038/nature12442. Epub 2013 Aug 18. Nature. 2013. PMID: 23955151
Platelet-derived growth factor-α receptor is the cellular receptor for human cytomegalovirus gHgLgO trimer.
Kabanova A, Marcandalli J, Zhou T, Bianchi S, Baxa U, Tsybovsky Y, Lilleri D, Silacci-Fregni C, Foglierini M, Fernandez-Rodriguez BM, Druz A, Zhang B, Geiger R, Pagani M, Sallusto F, Kwong PD, Corti D, Lanzavecchia A, Perez L. Kabanova A, et al. Among authors: perez l. Nat Microbiol. 2016 Jun 6;1(8):16082. doi: 10.1038/nmicrobiol.2016.82. Nat Microbiol. 2016. PMID: 27573107 Free PMC article.
A public antibody lineage that potently inhibits malaria infection through dual binding to the circumsporozoite protein.
Tan J, Sack BK, Oyen D, Zenklusen I, Piccoli L, Barbieri S, Foglierini M, Fregni CS, Marcandalli J, Jongo S, Abdulla S, Perez L, Corradin G, Varani L, Sallusto F, Sim BKL, Hoffman SL, Kappe SHI, Daubenberger C, Wilson IA, Lanzavecchia A. Tan J, et al. Among authors: perez l. Nat Med. 2018 May;24(4):401-407. doi: 10.1038/nm.4513. Epub 2018 Mar 19. Nat Med. 2018. PMID: 29554084 Free PMC article.
2,120 results