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LRH-1 agonism favours an immune-islet dialogue which protects against diabetes mellitus.
Cobo-Vuilleumier N, Lorenzo PI, Rodríguez NG, Herrera Gómez IG, Fuente-Martin E, López-Noriega L, Mellado-Gil JM, Romero-Zerbo SY, Baquié M, Lachaud CC, Stifter K, Perdomo G, Bugliani M, De Tata V, Bosco D, Parnaud G, Pozo D, Hmadcha A, Florido JP, Toscano MG, de Haan P, Schoonjans K, Sánchez Palazón L, Marchetti P, Schirmbeck R, Martín-Montalvo A, Meda P, Soria B, Bermúdez-Silva FJ, St-Onge L, Gauthier BR. Cobo-Vuilleumier N, et al. Among authors: perdomo g. Nat Commun. 2018 Apr 16;9(1):1488. doi: 10.1038/s41467-018-03943-0. Nat Commun. 2018. PMID: 29662071 Free PMC article.
Insulin degrading enzyme is up-regulated in pancreatic β cells by insulin treatment.
Fernández-Díaz CM, Escobar-Curbelo L, López-Acosta JF, Lobatón CD, Moreno A, Sanz-Ortega J, Perdomo G, Cózar-Castellano I. Fernández-Díaz CM, et al. Among authors: perdomo g. Histol Histopathol. 2018 Nov;33(11):1167-1180. doi: 10.14670/HH-11-997. Epub 2018 May 4. Histol Histopathol. 2018. PMID: 29726577 Free article.
Pancreatic β-cell-specific deletion of insulin-degrading enzyme leads to dysregulated insulin secretion and β-cell functional immaturity.
Fernández-Díaz CM, Merino B, López-Acosta JF, Cidad P, de la Fuente MA, Lobatón CD, Moreno A, Leissring MA, Perdomo G, Cózar-Castellano I. Fernández-Díaz CM, et al. Among authors: perdomo g. Am J Physiol Endocrinol Metab. 2019 Nov 1;317(5):E805-E819. doi: 10.1152/ajpendo.00040.2019. Epub 2019 Sep 3. Am J Physiol Endocrinol Metab. 2019. PMID: 31479304 Free PMC article.
Insulin-degrading enzyme ablation in mouse pancreatic alpha cells triggers cell proliferation, hyperplasia and glucagon secretion dysregulation.
Merino B, Casanueva-Álvarez E, Quesada I, González-Casimiro CM, Fernández-Díaz CM, Postigo-Casado T, Leissring MA, Kaestner KH, Perdomo G, Cózar-Castellano I. Merino B, et al. Among authors: perdomo g. Diabetologia. 2022 Aug;65(8):1375-1389. doi: 10.1007/s00125-022-05729-y. Epub 2022 Jun 2. Diabetologia. 2022. PMID: 35652923 Free PMC article.
Cyclin C stimulates β-cell proliferation in rat and human pancreatic β-cells.
Jiménez-Palomares M, López-Acosta JF, Villa-Pérez P, Moreno-Amador JL, Muñoz-Barrera J, Fernández-Luis S, Heras-Pozas B, Perdomo G, Bernal-Mizrachi E, Cózar-Castellano I. Jiménez-Palomares M, et al. Among authors: perdomo g. Am J Physiol Endocrinol Metab. 2015 Mar 15;308(6):E450-9. doi: 10.1152/ajpendo.00260.2014. Epub 2015 Jan 6. Am J Physiol Endocrinol Metab. 2015. PMID: 25564474 Free PMC article.
Differential central pathology and cognitive impairment in pre-diabetic and diabetic mice.
Ramos-Rodriguez JJ, Ortiz O, Jimenez-Palomares M, Kay KR, Berrocoso E, Murillo-Carretero MI, Perdomo G, Spires-Jones T, Cozar-Castellano I, Lechuga-Sancho AM, Garcia-Alloza M. Ramos-Rodriguez JJ, et al. Among authors: perdomo g. Psychoneuroendocrinology. 2013 Nov;38(11):2462-75. doi: 10.1016/j.psyneuen.2013.05.010. Epub 2013 Jun 21. Psychoneuroendocrinology. 2013. PMID: 23790682
Leptolide Improves Insulin Resistance in Diet-Induced Obese Mice.
Villa-Pérez P, Cueto M, Díaz-Marrero AR, Lobatón CD, Moreno A, Perdomo G, Cózar-Castellano I. Villa-Pérez P, et al. Among authors: perdomo g. Mar Drugs. 2017 Sep 15;15(9):289. doi: 10.3390/md15090289. Mar Drugs. 2017. PMID: 28914811 Free PMC article.
82 results