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FABP5 is important for cognitive function and is an important regulator of the physiological effects and pharmacokinetics of acute Δ9 tetrahydrocannabinol inhalation in mice.
Penman SL, Roeder NM, Berthold EC, Senetra AS, Marion M, Richardson BJ, White O, Fearby NL, McCurdy CR, Hamilton J, Sharma A, Thanos PK. Penman SL, et al. Pharmacol Biochem Behav. 2023 Oct;231:173633. doi: 10.1016/j.pbb.2023.173633. Epub 2023 Sep 15. Pharmacol Biochem Behav. 2023. PMID: 37716413
Vaporized Δ9-THC in utero results in reduced birthweight, increased locomotion, and altered wake-cycle activity dependent on dose, sex, and diet in the offspring.
Roeder NM, Penman SL, Richardson BJ, Wang J, Freeman-Striegel L, Khan A, Pareek O, Weiss M, Mohr P, Eiden RD, Chakraborty S, Thanos PK. Roeder NM, et al. Among authors: penman sl. Life Sci. 2024 Mar 1;340:122447. doi: 10.1016/j.lfs.2024.122447. Epub 2024 Jan 20. Life Sci. 2024. PMID: 38246518
First-in-human study of alpibectir (BVL-GSK098), a novel potent anti-TB drug.
Pieren M, Abáigar Gutiérrez-Solana A, Antonijoan Arbós RM, Boyle GW, Davila M, Davy M, Gitzinger M, Husband L, Martínez-Martínez MS, Mazarro DO, Pefani E, Penman SL, Remuiñán MJ, Vlasakakis G, Zeitlinger M, Dale GE. Pieren M, et al. Among authors: penman sl. J Antimicrob Chemother. 2024 Apr 24:dkae107. doi: 10.1093/jac/dkae107. Online ahead of print. J Antimicrob Chemother. 2024. PMID: 38656557
A first-in-class leucyl-tRNA synthetase inhibitor, ganfeborole, for rifampicin-susceptible tuberculosis: a phase 2a open-label, randomized trial.
Diacon AH, Barry CE 3rd, Carlton A, Chen RY, Davies M, de Jager V, Fletcher K, Koh GCKW, Kontsevaya I, Heyckendorf J, Lange C, Reimann M, Penman SL, Scott R, Maher-Edwards G, Tiberi S, Vlasakakis G, Upton CM, Aguirre DB. Diacon AH, et al. Among authors: penman sl. Nat Med. 2024 Mar;30(3):896-904. doi: 10.1038/s41591-024-02829-7. Epub 2024 Feb 16. Nat Med. 2024. PMID: 38365949 Free PMC article. Clinical Trial.
17 results