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Dual-Target Inhibitors of the Folate Pathway Inhibit Intrinsically Trimethoprim-Resistant DfrB Dihydrofolate Reductases.
Toulouse JL, Shi G, Lemay-St-Denis C, Ebert MCCJC, Deon D, Gagnon M, Ruediger E, Saint-Jacques K, Forge D, Vanden Eynde JJ, Marinier A, Ji X, Pelletier JN. Toulouse JL, et al. Among authors: pelletier jn. ACS Med Chem Lett. 2020 Sep 28;11(11):2261-2267. doi: 10.1021/acsmedchemlett.0c00393. eCollection 2020 Nov 12. ACS Med Chem Lett. 2020. PMID: 33214838 Free PMC article.
Development of sulfahydantoin derivatives as β-lactamase inhibitors.
Paquet-Côté PA, Alejaldre L, Lapointe Verreault C, Gobeil SMC, Lamoureux R, Bédard L, Normandeau CO, Lemay-St-Denis C, Pelletier JN, Voyer N. Paquet-Côté PA, et al. Among authors: pelletier jn. Bioorg Med Chem Lett. 2021 Mar 1;35:127781. doi: 10.1016/j.bmcl.2021.127781. Epub 2021 Jan 8. Bioorg Med Chem Lett. 2021. PMID: 33422604
Integrating dynamics into enzyme engineering.
Lemay-St-Denis C, Doucet N, Pelletier JN. Lemay-St-Denis C, et al. Among authors: pelletier jn. Protein Eng Des Sel. 2022 Feb 17;35:gzac015. doi: 10.1093/protein/gzac015. Protein Eng Des Sel. 2022. PMID: 36416215
Discovery of Highly Trimethoprim-Resistant DfrB Dihydrofolate Reductases in Diverse Environmental Settings Suggests an Evolutionary Advantage Unrelated to Antibiotic Resistance.
Cellier-Goetghebeur S, Lafontaine K, Lemay-St-Denis C, Tsamo P, Bonneau-Burke A, Copp JN, Pelletier JN. Cellier-Goetghebeur S, et al. Among authors: pelletier jn. Antibiotics (Basel). 2022 Dec 7;11(12):1768. doi: 10.3390/antibiotics11121768. Antibiotics (Basel). 2022. PMID: 36551425 Free PMC article.
Tuning Selectivity in CalA Lipase: Beyond Tunnel Engineering.
Alejaldre L, Lemay-St-Denis C, Pelletier JN, Quaglia D. Alejaldre L, et al. Among authors: pelletier jn. Biochemistry. 2023 Jan 17;62(2):396-409. doi: 10.1021/acs.biochem.2c00513. Epub 2022 Dec 29. Biochemistry. 2023. PMID: 36580299 Free PMC article.
A conserved SH3-like fold in diverse putative proteins tetramerizes into an oxidoreductase providing an antimicrobial resistance phenotype.
Lemay-St-Denis C, Alejaldre L, Jemouai Z, Lafontaine K, St-Aubin M, Hitache K, Valikhani D, Weerasinghe NW, Létourneau M, Thibodeaux CJ, Doucet N, Baron C, Copp JN, Pelletier JN. Lemay-St-Denis C, et al. Among authors: pelletier jn. Philos Trans R Soc Lond B Biol Sci. 2023 Feb 27;378(1871):20220040. doi: 10.1098/rstb.2022.0040. Epub 2023 Jan 11. Philos Trans R Soc Lond B Biol Sci. 2023. PMID: 36633286 Free PMC article.
92 results