Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Text availability

Article attribute

Article type

Publication date

Search Results

148 results

Filters applied: . Clear all
Results are displayed in a computed author sort order. The Results By Year timeline is not available.
Page 1
Pathogenic NLRP3 mutants form constitutively active inflammasomes resulting in immune-metabolic limitation of IL-1β production.
Molina-López C, Hurtado-Navarro L, García CJ, Angosto-Bazarra D, Vallejo F, Tapia-Abellán A, Marques-Soares JR, Vargas C, Bujan-Rivas S, Tomás-Barberán FA, Arostegui JI, Pelegrin P. Molina-López C, et al. Among authors: pelegrin p. Nat Commun. 2024 Feb 6;15(1):1096. doi: 10.1038/s41467-024-44990-0. Nat Commun. 2024. PMID: 38321014 Free PMC article.
MCC950 closes the active conformation of NLRP3 to an inactive state.
Tapia-Abellán A, Angosto-Bazarra D, Martínez-Banaclocha H, de Torre-Minguela C, Cerón-Carrasco JP, Pérez-Sánchez H, Arostegui JI, Pelegrin P. Tapia-Abellán A, et al. Among authors: pelegrin p. Nat Chem Biol. 2019 Jun;15(6):560-564. doi: 10.1038/s41589-019-0278-6. Epub 2019 May 13. Nat Chem Biol. 2019. PMID: 31086329 Free PMC article.
The NLRP3 inflammasome is released as a particulate danger signal that amplifies the inflammatory response.
Baroja-Mazo A, Martín-Sánchez F, Gomez AI, Martínez CM, Amores-Iniesta J, Compan V, Barberà-Cremades M, Yagüe J, Ruiz-Ortiz E, Antón J, Buján S, Couillin I, Brough D, Arostegui JI, Pelegrín P. Baroja-Mazo A, et al. Among authors: pelegrin p. Nat Immunol. 2014 Aug;15(8):738-48. doi: 10.1038/ni.2919. Epub 2014 Jun 22. Nat Immunol. 2014. PMID: 24952504
P2X7 receptor induces mitochondrial failure in monocytes and compromises NLRP3 inflammasome activation during sepsis.
Martínez-García JJ, Martínez-Banaclocha H, Angosto-Bazarra D, de Torre-Minguela C, Baroja-Mazo A, Alarcón-Vila C, Martínez-Alarcón L, Amores-Iniesta J, Martín-Sánchez F, Ercole GA, Martínez CM, González-Lisorge A, Fernández-Pacheco J, Martínez-Gil P, Adriouch S, Koch-Nolte F, Luján J, Acosta-Villegas F, Parrilla P, García-Palenciano C, Pelegrin P. Martínez-García JJ, et al. Among authors: pelegrin p. Nat Commun. 2019 Jun 20;10(1):2711. doi: 10.1038/s41467-019-10626-x. Nat Commun. 2019. PMID: 31221993 Free PMC article.
Addendum: MCC950 closes the active conformation of NLRP3 to an inactive state.
Tapia-Abellán A, Angosto-Bazarra D, Martínez-Banaclocha H, de Torre-Minguela C, Cerón-Carrasco JP, Pérez-Sánchez H, Arostegui JI, Pelegrin P. Tapia-Abellán A, et al. Among authors: pelegrin p. Nat Chem Biol. 2021 Mar;17(3):361. doi: 10.1038/s41589-021-00741-6. Nat Chem Biol. 2021. PMID: 33495649
Assessment of ASC Oligomerization by Flow Cytometry.
Hurtado-Navarro L, Baroja-Mazo A, Martínez-Banaclocha H, Pelegrín P. Hurtado-Navarro L, et al. Among authors: pelegrin p. Methods Mol Biol. 2022;2459:1-9. doi: 10.1007/978-1-0716-2144-8_1. Methods Mol Biol. 2022. PMID: 35212949
148 results