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Discovery of Inhibitor of Wnt Production 2 (IWP-2) and Related Compounds As Selective ATP-Competitive Inhibitors of Casein Kinase 1 (CK1) δ/ε.
García-Reyes B, Witt L, Jansen B, Karasu E, Gehring T, Leban J, Henne-Bruns D, Pichlo C, Brunstein E, Baumann U, Wesseler F, Rathmer B, Schade D, Peifer C, Knippschild U. García-Reyes B, et al. Among authors: peifer c. J Med Chem. 2018 May 10;61(9):4087-4102. doi: 10.1021/acs.jmedchem.8b00095. Epub 2018 May 1. J Med Chem. 2018. PMID: 29630366
Axitinib: A Photoswitchable Approved Tyrosine Kinase Inhibitor.
Schmidt D, Rodat T, Heintze L, Weber J, Horbert R, Girreser U, Raeker T, Bußmann L, Kriegs M, Hartke B, Peifer C. Schmidt D, et al. Among authors: peifer c. ChemMedChem. 2018 Nov 20;13(22):2415-2426. doi: 10.1002/cmdc.201800531. Epub 2018 Nov 5. ChemMedChem. 2018. PMID: 30199151
2-Azo-, 2-diazocine-thiazols and 2-azo-imidazoles as photoswitchable kinase inhibitors: limitations and pitfalls of the photoswitchable inhibitor approach.
Schehr M , Ianes C , Weisner J , Heintze L , Müller MP , Pichlo C , Charl J , Brunstein E , Ewert J , Lehr M , Baumann U , Rauh D , Knippschild U , Peifer C , Herges R . Schehr M , et al. Among authors: peifer c. Photochem Photobiol Sci. 2019 Jun 12;18(6):1398-1407. doi: 10.1039/c9pp00010k. Photochem Photobiol Sci. 2019. PMID: 30924488
Phenotypic Discovery of Triazolo[1,5-c]quinazolines as a First-In-Class Bone Morphogenetic Protein Amplifier Chemotype.
Wesseler F, Lohmann S, Riege D, Halver J, Roth A, Pichlo C, Weber S, Takamiya M, Müller E, Ketzel J, Flegel J, Gihring A, Rastegar S, Bertrand J, Baumann U, Knippschild U, Peifer C, Sievers S, Waldmann H, Schade D. Wesseler F, et al. Among authors: peifer c. J Med Chem. 2022 Nov 24;65(22):15263-15281. doi: 10.1021/acs.jmedchem.2c01199. Epub 2022 Nov 8. J Med Chem. 2022. PMID: 36346705
Zebrafish as model system for the biological characterization of CK1 inhibitors.
Meier L, Gahr BM, Roth A, Gihring A, Kirschner S, Woitaske-Proske C, Baier J, Peifer C, Just S, Knippschild U. Meier L, et al. Among authors: peifer c. Front Pharmacol. 2023 Sep 11;14:1245246. doi: 10.3389/fphar.2023.1245246. eCollection 2023. Front Pharmacol. 2023. PMID: 37753113 Free PMC article.
Photoactivatable Prodrugs of Antimelanoma Agent Vemurafenib.
Horbert R, Pinchuk B, Davies P, Alessi D, Peifer C. Horbert R, et al. Among authors: peifer c. ACS Chem Biol. 2015 Sep 18;10(9):2099-107. doi: 10.1021/acschembio.5b00174. Epub 2015 Jul 10. ACS Chem Biol. 2015. PMID: 26061392
A CK1 FRET biosensor reveals that DDX3X is an essential activator of CK1ε.
Dolde C, Bischof J, Grüter S, Montada A, Halekotte J, Peifer C, Kalbacher H, Baumann U, Knippschild U, Suter B. Dolde C, et al. Among authors: peifer c. J Cell Sci. 2018 Jan 4;131(1):jcs207316. doi: 10.1242/jcs.207316. J Cell Sci. 2018. PMID: 29222110 Free PMC article.
86 results