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The ClC-1 chloride channel inhibitor NMD670 improves skeletal muscle function in rat models and patients with myasthenia gravis.
Skov M, Ruijs TQ, Grønnebæk TS, Skals M, Riisager A, Winther JB, Dybdahl KLT, Findsen A, Morgen JJ, Huus N, Broch-Lips M, Nielsen OB, de Cuba CMKE, Heuberger JAAC, de Kam ML, Tannemaat M, Verschuuren JJGM, Knutsen LJS, Kelly NM, Jensen KG, Arnold WD, Burghes AH, Olesen C, Bold J, Petersen TK, Quiroz JA, Hutchison J, Chin ER, Groeneveld GJ, Pedersen TH. Skov M, et al. Among authors: pedersen th. Sci Transl Med. 2024 Mar 20;16(739):eadk9109. doi: 10.1126/scitranslmed.adk9109. Epub 2024 Mar 20. Sci Transl Med. 2024. PMID: 38507469 Clinical Trial.
Six weeks of high-load resistance and low-load blood flow restricted training increase Na/K-ATPase sub-units α2 and β1 equally, but does not alter ClC-1 abundance in untrained human skeletal muscle.
Wang J, Rindom E, Groennebaek T, Sieljacks P, Jakobsgaard JE, Farup J, Vissing K, Pedersen TH, de Paoli FV. Wang J, et al. Among authors: pedersen th. J Muscle Res Cell Motil. 2023 Mar;44(1):25-36. doi: 10.1007/s10974-023-09644-6. Epub 2023 Apr 4. J Muscle Res Cell Motil. 2023. PMID: 37014477 Clinical Trial.
91 results