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Discovery of Anthranilic Acid Derivatives as Difluoromethylornithine Adjunct Agents That Inhibit Far Upstream Element Binding Protein 1 (FUBP1) Function.
Dobrovolskaite A, Moots H, Tantak MP, Shah K, Thomas J, Dinara S, Massaro C, Hershberger PM, Maloney PR, Peddibhotla S, Sugarman E, Litherland S, Arnoletti JP, Jha RK, Levens D, Phanstiel O 4th. Dobrovolskaite A, et al. Among authors: peddibhotla s. J Med Chem. 2022 Nov 24;65(22):15391-15415. doi: 10.1021/acs.jmedchem.2c01350. Epub 2022 Nov 16. J Med Chem. 2022. PMID: 36382923 Free PMC article.
A JAM-A-tetraspanin-αvβ5 integrin complex regulates contact inhibition of locomotion.
Kummer D, Steinbacher T, Thölmann S, Schwietzer MF, Hartmann C, Horenkamp S, Demuth S, Peddibhotla SSD, Brinkmann F, Kemper B, Schnekenburger J, Brandt M, Betz T, Liashkovich I, Kouzel IU, Shahin V, Corvaia N, Rottner K, Tarbashevich K, Raz E, Greune L, Schmidt MA, Gerke V, Ebnet K. Kummer D, et al. Among authors: peddibhotla ssd. J Cell Biol. 2022 Apr 4;221(4):e202105147. doi: 10.1083/jcb.202105147. Epub 2022 Mar 16. J Cell Biol. 2022. PMID: 35293964 Free PMC article.
An Optimized Dihydrodibenzothiazepine Lead Compound (SBI-0797750) as a Potent and Selective Inhibitor of Plasmodium falciparum and P. vivax Glucose 6-Phosphate Dehydrogenase 6-Phosphogluconolactonase.
Berneburg I, Peddibhotla S, Heimsch KC, Haeussler K, Maloney P, Gosalia P, Preuss J, Rahbari M, Skorokhod O, Valente E, Ulliers D, Simula LF, Buchholz K, Hedrick MP, Hershberger P, Chung TDY, Jackson MR, Schwarzer E, Rahlfs S, Bode L, Becker K, Pinkerton AB. Berneburg I, et al. Among authors: peddibhotla s. Antimicrob Agents Chemother. 2022 Apr 19;66(4):e0210921. doi: 10.1128/aac.02109-21. Epub 2022 Mar 10. Antimicrob Agents Chemother. 2022. PMID: 35266827 Free PMC article.
Discovery of small molecule guanylyl cyclase A receptor positive allosteric modulators.
Sangaralingham SJ, Whig K, Peddibhotla S, Kirby RJ, Sessions HE, Maloney PR, Hershberger PM, Mose-Yates H, Hood BL, Vasile S, Pan S, Zheng Y, Malany S, Burnett JC Jr. Sangaralingham SJ, et al. Among authors: peddibhotla s. Proc Natl Acad Sci U S A. 2021 Dec 28;118(52):e2109386118. doi: 10.1073/pnas.2109386118. Proc Natl Acad Sci U S A. 2021. PMID: 34930837 Free PMC article.
Optimization of a urea-containing series of nicotinamide phosphoribosyltransferase (NAMPT) activators.
Pinkerton AB, Sessions EH, Hershberger P, Maloney PR, Peddibhotla S, Hopf M, Sergienko E, Ma CT, Smith LH, Jackson MR, Tanaka J, Tsuji T, Akiu M, Cohen SE, Nakamura T, Gardell SJ. Pinkerton AB, et al. Among authors: peddibhotla s. Bioorg Med Chem Lett. 2021 Jun 1;41:128007. doi: 10.1016/j.bmcl.2021.128007. Epub 2021 Mar 31. Bioorg Med Chem Lett. 2021. PMID: 33798699
β-Arrestin-Biased Allosteric Modulator of NTSR1 Selectively Attenuates Addictive Behaviors.
Slosky LM, Bai Y, Toth K, Ray C, Rochelle LK, Badea A, Chandrasekhar R, Pogorelov VM, Abraham DM, Atluri N, Peddibhotla S, Hedrick MP, Hershberger P, Maloney P, Yuan H, Li Z, Wetsel WC, Pinkerton AB, Barak LS, Caron MG. Slosky LM, et al. Among authors: peddibhotla s. Cell. 2020 Jun 11;181(6):1364-1379.e14. doi: 10.1016/j.cell.2020.04.053. Epub 2020 May 28. Cell. 2020. PMID: 32470395 Free PMC article.
56 results