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Cystathionine β-Synthase in Physiology and Cancer.
Zhu H, Blake S, Chan KT, Pearson RB, Kang J. Zhu H, et al. Among authors: pearson rb. Biomed Res Int. 2018 Jun 28;2018:3205125. doi: 10.1155/2018/3205125. eCollection 2018. Biomed Res Int. 2018. PMID: 30050925 Free PMC article. Review.
Combination Therapy Targeting Ribosome Biogenesis and mRNA Translation Synergistically Extends Survival in MYC-Driven Lymphoma.
Devlin JR, Hannan KM, Hein N, Cullinane C, Kusnadi E, Ng PY, George AJ, Shortt J, Bywater MJ, Poortinga G, Sanij E, Kang J, Drygin D, O'Brien S, Johnstone RW, McArthur GA, Hannan RD, Pearson RB. Devlin JR, et al. Among authors: pearson rb. Cancer Discov. 2016 Jan;6(1):59-70. doi: 10.1158/2159-8290.CD-14-0673. Epub 2015 Oct 21. Cancer Discov. 2016. PMID: 26490423
Inhibition of RNA polymerase I transcription initiation by CX-5461 activates non-canonical ATM/ATR signaling.
Quin J, Chan KT, Devlin JR, Cameron DP, Diesch J, Cullinane C, Ahern J, Khot A, Hein N, George AJ, Hannan KM, Poortinga G, Sheppard KE, Khanna KK, Johnstone RW, Drygin D, McArthur GA, Pearson RB, Sanij E, Hannan RD. Quin J, et al. Among authors: pearson rb. Oncotarget. 2016 Aug 2;7(31):49800-49818. doi: 10.18632/oncotarget.10452. Oncotarget. 2016. PMID: 27391441 Free PMC article.
A functional genetic screen defines the AKT-induced senescence signaling network.
Chan KT, Blake S, Zhu H, Kang J, Trigos AS, Madhamshettiwar PB, Diesch J, Paavolainen L, Horvath P, Hannan RD, George AJ, Sanij E, Hannan KM, Simpson KJ, Pearson RB. Chan KT, et al. Among authors: pearson rb. Cell Death Differ. 2020 Feb;27(2):725-741. doi: 10.1038/s41418-019-0384-8. Epub 2019 Jul 8. Cell Death Differ. 2020. PMID: 31285545 Free PMC article.
Regulation of PRMT5-MDM4 axis is critical in the response to CDK4/6 inhibitors in melanoma.
AbuHammad S, Cullinane C, Martin C, Bacolas Z, Ward T, Chen H, Slater A, Ardley K, Kirby L, Chan KT, Brajanovski N, Smith LK, Rao AD, Lelliott EJ, Kleinschmidt M, Vergara IA, Papenfuss AT, Lau P, Ghosh P, Haupt S, Haupt Y, Sanij E, Poortinga G, Pearson RB, Falk H, Curtis DJ, Stupple P, Devlin M, Street I, Davies MA, McArthur GA, Sheppard KE. AbuHammad S, et al. Among authors: pearson rb. Proc Natl Acad Sci U S A. 2019 Sep 3;116(36):17990-18000. doi: 10.1073/pnas.1901323116. Epub 2019 Aug 22. Proc Natl Acad Sci U S A. 2019. PMID: 31439820 Free PMC article.
Neurokinin-1 receptor is an effective target for treating leukemia by inducing oxidative stress through mitochondrial calcium overload.
Ge C, Huang H, Huang F, Yang T, Zhang T, Wu H, Zhou H, Chen Q, Shi Y, Sun Y, Liu L, Wang X, Pearson RB, Cao Y, Kang J, Fu C. Ge C, et al. Among authors: pearson rb. Proc Natl Acad Sci U S A. 2019 Sep 24;116(39):19635-19645. doi: 10.1073/pnas.1908998116. Epub 2019 Sep 5. Proc Natl Acad Sci U S A. 2019. PMID: 31488714 Free PMC article.
155 results