Pearson CE - Search Results

1

A slipped-CAG DNA-binding small molecule induces trinucleotide-repeat contractions in vivo.

Nakamori M, Panigrahi GB, Lanni S, Gall-Duncan T, Hayakawa H, Tanaka H, Luo J, Otabe T, Li J, Sakata A, Caron MC, Joshi N, Prasolava T, Chiang K, Masson JY, Wold MS, Wang X, Lee MYWT, Huddleston J, Munson KM, Davidson S, Layeghifard M, Edward LM, Gallon R, Santibanez-Koref M, Murata A, Takahashi MP, Eichler EE, Shlien A, Nakatani K, Mochizuki H, Pearson CE. Nakamori M, et al. Among authors: pearson ce. Nat Genet. 2020 Feb;52(2):146-159. doi: 10.1038/s41588-019-0575-8. Epub 2020 Feb 14. Nat Genet. 2020. PMID: 32060489 Free PMC article.

2

Interruptions in the triplet repeats of SCA1 and FRAXA reduce the propensity and complexity of slipped strand DNA (S-DNA) formation.

Pearson CE, Eichler EE, Lorenzetti D, Kramer SF, Zoghbi HY, Nelson DL, Sinden RR. Pearson CE, et al. Biochemistry. 1998 Feb 24;37(8):2701-8. doi: 10.1021/bi972546c. Biochemistry. 1998. PMID: 9485421

3

Trinucleotide repeat DNA structures: dynamic mutations from dynamic DNA.

Pearson CE, Sinden RR. Pearson CE, et al. Curr Opin Struct Biol. 1998 Jun;8(3):321-30. doi: 10.1016/s0959-440x(98)80065-1. Curr Opin Struct Biol. 1998. PMID: 9666328 Review.

4

In vitro (CTG)*(CAG) expansions and deletions by human cell extracts.

Panigrahi GB, Cleary JD, Pearson CE. Panigrahi GB, et al. Among authors: pearson ce. J Biol Chem. 2002 Apr 19;277(16):13926-34. doi: 10.1074/jbc.M109761200. Epub 2002 Feb 6. J Biol Chem. 2002. PMID: 11832482 Free article.

5

Evidence of cis-acting factors in replication-mediated trinucleotide repeat instability in primate cells.

Cleary JD, Nichol K, Wang YH, Pearson CE. Cleary JD, et al. Among authors: pearson ce. Nat Genet. 2002 May;31(1):37-46. doi: 10.1038/ng870. Epub 2002 Apr 22. Nat Genet. 2002. PMID: 11967533

6

Genomic context drives SCA7 CAG repeat instability, while expressed SCA7 cDNAs are intergenerationally and somatically stable in transgenic mice.

Libby RT, Monckton DG, Fu YH, Martinez RA, McAbney JP, Lau R, Einum DD, Nichol K, Ware CB, Ptacek LJ, Pearson CE, La Spada AR. Libby RT, et al. Among authors: pearson ce. Hum Mol Genet. 2003 Jan 1;12(1):41-50. doi: 10.1093/hmg/ddg006. Hum Mol Genet. 2003. PMID: 12490531

7

Fidelity of primate cell repair of a double-strand break within a (CTG).(CAG) tract. Effect of slipped DNA structures.

Marcadier JL, Pearson CE. Marcadier JL, et al. Among authors: pearson ce. J Biol Chem. 2003 Sep 5;278(36):33848-56. doi: 10.1074/jbc.M304284200. Epub 2003 Jun 14. J Biol Chem. 2003. PMID: 12807901 Free article.

8

The contribution of cis-elements to disease-associated repeat instability: clinical and experimental evidence.

Cleary JD, Pearson CE. Cleary JD, et al. Among authors: pearson ce. Cytogenet Genome Res. 2003;100(1-4):25-55. doi: 10.1159/000072837. Cytogenet Genome Res. 2003. PMID: 14526163 Review.

9

Replication inhibitors modulate instability of an expanded trinucleotide repeat at the myotonic dystrophy type 1 disease locus in human cells.

Yang Z, Lau R, Marcadier JL, Chitayat D, Pearson CE. Yang Z, et al. Among authors: pearson ce. Am J Hum Genet. 2003 Nov;73(5):1092-105. doi: 10.1086/379523. Epub 2003 Oct 21. Am J Hum Genet. 2003. PMID: 14574643 Free PMC article.

10

Slipping while sleeping? Trinucleotide repeat expansions in germ cells.

Pearson CE. Pearson CE. Trends Mol Med. 2003 Nov;9(11):490-5. doi: 10.1016/j.molmed.2003.09.006. Trends Mol Med. 2003. PMID: 14604827 Review.

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