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A novel series of potent and selective ketone histone deacetylase inhibitors with antitumor activity in vivo.
J Med Chem. 2008 Apr 24;51(8):2350-3. doi: 10.1021/jm800079s. Epub 2008 Mar 28.
J Med Chem. 2008.
PMID: 18370373
Discovery and synthesis of HIV integrase inhibitors: development of potent and orally bioavailable N-methyl pyrimidones.
Gardelli C, Nizi E, Muraglia E, Crescenzi B, Ferrara M, Orvieto F, Pace P, Pescatore G, Poma M, Ferreira Mdel R, Scarpelli R, Homnick CF, Ikemoto N, Alfieri A, Verdirame M, Bonelli F, Paz OG, Taliani M, Monteagudo E, Pesci S, Laufer R, Felock P, Stillmock KA, Hazuda D, Rowley M, Summa V.
Gardelli C, et al. Among authors: paz og.
J Med Chem. 2007 Oct 4;50(20):4953-75. doi: 10.1021/jm0704705. Epub 2007 Sep 8.
J Med Chem. 2007.
PMID: 17824681
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4,5-dihydroxypyrimidine carboxamides and N-alkyl-5-hydroxypyrimidinone carboxamides are potent, selective HIV integrase inhibitors with good pharmacokinetic profiles in preclinical species.
Summa V, Petrocchi A, Matassa VG, Gardelli C, Muraglia E, Rowley M, Paz OG, Laufer R, Monteagudo E, Pace P.
Summa V, et al. Among authors: paz og.
J Med Chem. 2006 Nov 16;49(23):6646-9. doi: 10.1021/jm060854f.
J Med Chem. 2006.
PMID: 17154493
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Quantitative prediction of human clearance guiding the development of Raltegravir (MK-0518, isentress) and related HIV integrase inhibitors.
Laufer R, Paz OG, Di Marco A, Bonelli F, Monteagudo E, Summa V, Rowley M.
Laufer R, et al. Among authors: paz og.
Drug Metab Dispos. 2009 Apr;37(4):873-83. doi: 10.1124/dmd.108.023804. Epub 2009 Jan 14.
Drug Metab Dispos. 2009.
PMID: 19144773
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Liver-specific alpha 2 interferon gene expression results in protection from induced hepatitis.
Aurisicchio L, Delmastro P, Salucci V, Paz OG, Rovere P, Ciliberto G, La Monica N, Palombo F.
Aurisicchio L, et al. Among authors: paz og.
J Virol. 2000 May;74(10):4816-23. doi: 10.1128/jvi.74.10.4816-4823.2000.
J Virol. 2000.
PMID: 10775620
Free PMC article.
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The novel anthracenedione, pixantrone, lacks redox activity and inhibits doxorubicinol formation in human myocardium: insight to explain the cardiac safety of pixantrone in doxorubicin-treated patients.
Salvatorelli E, Menna P, Paz OG, Chello M, Covino E, Singer JW, Minotti G.
Salvatorelli E, et al. Among authors: paz og.
J Pharmacol Exp Ther. 2013 Feb;344(2):467-78. doi: 10.1124/jpet.112.200568. Epub 2012 Nov 28.
J Pharmacol Exp Ther. 2013.
PMID: 23192654
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Multidrug resistance-reversing agents increase vinblastine distribution in normal tissues expressing the P-glycoprotein but do not enhance drug penetration in brain and testis.
Arboix M, Paz OG, Colombo T, D'Incalci M.
Arboix M, et al. Among authors: paz og.
J Pharmacol Exp Ther. 1997 Jun;281(3):1226-30.
J Pharmacol Exp Ther. 1997.
PMID: 9190857
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Anthracycline cardiotoxicity.
Menna P, Paz OG, Chello M, Covino E, Salvatorelli E, Minotti G.
Menna P, et al. Among authors: paz og.
Expert Opin Drug Saf. 2012 May;11 Suppl 1:S21-36. doi: 10.1517/14740338.2011.589834. Epub 2011 Jun 2.
Expert Opin Drug Saf. 2012.
PMID: 21635149
Review.
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