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Triazole-based estradiol dimers prepared via CuAAC from 17α-ethinyl estradiol with five-atom linkers causing G2/M arrest and tubulin inhibition.
Jurášek M, Řehulka J, Hrubá L, Ivanová A, Gurská S, Mokshyna O, Trousil P, Huml L, Polishchuk P, Hajdúch M, Drašar PB, Džubák P. Jurášek M, et al. Among authors: drasar pb. Bioorg Chem. 2023 Feb;131:106334. doi: 10.1016/j.bioorg.2022.106334. Epub 2022 Dec 23. Bioorg Chem. 2023. PMID: 36592487 Free article.
Synthesis and biological evaluation of cationic TopFluor cholesterol analogues.
Jurášek M, Valečka J, Novotný I, Kejík Z, Fähnrich J, Marešová A, Tauchen J, Bartůněk P, Dolenský B, Jakubek M, Drašar PB, Králová J. Jurášek M, et al. Among authors: drasar pb. Bioorg Chem. 2021 Dec;117:105410. doi: 10.1016/j.bioorg.2021.105410. Epub 2021 Oct 6. Bioorg Chem. 2021. PMID: 34700109
Estradiol dimer inhibits tubulin polymerization and microtubule dynamics.
Jurášek M, Černohorská M, Řehulka J, Spiwok V, Sulimenko T, Dráberová E, Darmostuk M, Gurská S, Frydrych I, Buriánová R, Ruml T, Hajdúch M, Bartůněk P, Dráber P, Džubák P, Drašar PB, Sedlák D. Jurášek M, et al. Among authors: drasar pb. J Steroid Biochem Mol Biol. 2018 Oct;183:68-79. doi: 10.1016/j.jsbmb.2018.05.008. Epub 2018 May 24. J Steroid Biochem Mol Biol. 2018. PMID: 29803726
16 results