Pauly GT - Search Results

1

Ezrin Inhibition Up-regulates Stress Response Gene Expression.

Çelik H, Bulut G, Han J, Graham GT, Minas TZ, Conn EJ, Hong SH, Pauly GT, Hayran M, Li X, Özdemirli M, Ayhan A, Rudek MA, Toretsky JA, Üren A. Çelik H, et al. Among authors: pauly gt. J Biol Chem. 2016 Jun 17;291(25):13257-70. doi: 10.1074/jbc.M116.718189. Epub 2016 May 2. J Biol Chem. 2016. PMID: 27137931 Free PMC article.

2

Substitution of aminomethyl at the meta-position enhances the inactivation of O6-alkylguanine-DNA alkyltransferase by O6-benzylguanine.

Pauly GT, Loktionova NA, Fang Q, Vankayala SL, Guida WC, Pegg AE. Pauly GT, et al. J Med Chem. 2008 Nov 27;51(22):7144-53. doi: 10.1021/jm800675p. J Med Chem. 2008. PMID: 18973327 Free PMC article.

3

Blocking downstream signaling pathways in the context of HDAC inhibition promotes apoptosis preferentially in cells harboring mutant Ras.

Bahr JC, Robey RW, Luchenko V, Basseville A, Chakraborty AR, Kozlowski H, Pauly GT, Patel P, Schneider JP, Gottesman MM, Bates SE. Bahr JC, et al. Among authors: pauly gt. Oncotarget. 2016 Oct 25;7(43):69804-69815. doi: 10.18632/oncotarget.12001. Oncotarget. 2016. PMID: 27634878 Free PMC article.

4

Botryllamide G is an ABCG2 inhibitor that improves lapatinib delivery in mouse brain.

Strope JD, Peer CJ, Sissung TM, Hall OM, Huang PA, Harris EM, Gustafson KR, Henrich CJ, Sigano DM, Pauly GT, Schneider JP, Bates SE, Figg WD. Strope JD, et al. Among authors: pauly gt. Cancer Biol Ther. 2020;21(3):223-230. doi: 10.1080/15384047.2019.1683324. Epub 2019 Nov 10. Cancer Biol Ther. 2020. PMID: 31709896 Free PMC article.

5

Reaction of O6-benzylguanine-resistant mutants of human O6-alkylguanine-DNA alkyltransferase with O6-benzylguanine in oligodeoxyribonucleotides.

Pegg AE, Kanugula S, Edara S, Pauly GT, Moschel RC, Goodtzova K. Pegg AE, et al. Among authors: pauly gt. J Biol Chem. 1998 May 1;273(18):10863-7. doi: 10.1074/jbc.273.18.10863. J Biol Chem. 1998. PMID: 9556560 Free article.

6

Inactivation of O(6)-alkylguanine-DNA alkyltransferase by folate esters of O(6)-benzyl-2'-deoxyguanosine and of O(6)-[4-(hydroxymethyl)benzyl]guanine.

Javanmard S, Loktionova NA, Fang Q, Pauly GT, Pegg AE, Moschel RC. Javanmard S, et al. Among authors: pauly gt. J Med Chem. 2007 Oct 18;50(21):5193-201. doi: 10.1021/jm0705859. Epub 2007 Sep 20. J Med Chem. 2007. PMID: 17880193 Free PMC article.

7

Creatine riboside is a cancer cell-derived metabolite associated with arginine auxotrophy.

Parker AL, Toulabi L, Oike T, Kanke Y, Patel D, Tada T, Taylor S, Beck JA, Bowman E, Reyzer ML, Butcher D, Kuhn S, Pauly GT, Krausz KW, Gonzalez FJ, Hussain SP, Ambs S, Ryan BM, Wang XW, Harris CC. Parker AL, et al. Among authors: pauly gt. J Clin Invest. 2022 Jul 15;132(14):e157410. doi: 10.1172/JCI157410. J Clin Invest. 2022. PMID: 35838048 Free PMC article.

8

The small molecule NSC676914A is cytotoxic and differentially affects NFκB signaling in ovarian cancer cells and HEK293 cells.

Sagher E, Hernandez L, Heywood C, Pauly GT, Young MR, Schneider J, Colburn NH, Annunziata CM. Sagher E, et al. Among authors: pauly gt. Cancer Cell Int. 2014 Aug 12;14:75. doi: 10.1186/s12935-014-0075-y. eCollection 2014. Cancer Cell Int. 2014. PMID: 25324692 Free PMC article.

9

Rilpivirine and Doravirine Have Complementary Efficacies Against NNRTI-Resistant HIV-1 Mutants.

Smith SJ, Pauly GT, Akram A, Melody K, Ambrose Z, Schneider JP, Hughes SH. Smith SJ, et al. Among authors: pauly gt. J Acquir Immune Defic Syndr. 2016 Aug 15;72(5):485-91. doi: 10.1097/QAI.0000000000001031. J Acquir Immune Defic Syndr. 2016. PMID: 27124362 Free PMC article.

10

Structure-based non-nucleoside inhibitor design: Developing inhibitors that are effective against resistant mutants.

Smith SJ, Pauly GT, Hewlett K, Schneider JP, Hughes SH. Smith SJ, et al. Among authors: pauly gt. Chem Biol Drug Des. 2021 Jan;97(1):4-17. doi: 10.1111/cbdd.13766. Epub 2020 Sep 17. Chem Biol Drug Des. 2021. PMID: 32743937 Free PMC article.

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