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Differences in syncytia formation by SARS-CoV-2 variants modify host chromatin accessibility and cellular senescence via TP53.
Lee JD, Menasche BL, Mavrikaki M, Uyemura MM, Hong SM, Kozlova N, Wei J, Alfajaro MM, Filler RB, Müller A, Saxena T, Posey RR, Cheung P, Muranen T, Heng YJ, Paulo JA, Wilen CB, Slack FJ. Lee JD, et al. Among authors: paulo ja. Cell Rep. 2023 Dec 26;42(12):113478. doi: 10.1016/j.celrep.2023.113478. Epub 2023 Nov 21. Cell Rep. 2023. PMID: 37991919 Free PMC article.
ALS-related p97 R155H mutation disrupts lysophagy in iPSC-derived motor neurons.
Klickstein JA, Johnson MA, Antonoudiou P, Maguire J, Paulo JA, Gygi SP, Weihl C, Raman M. Klickstein JA, et al. Among authors: paulo ja. Stem Cell Reports. 2024 Mar 12;19(3):366-382. doi: 10.1016/j.stemcr.2024.01.002. Epub 2024 Feb 8. Stem Cell Reports. 2024. PMID: 38335961 Free PMC article.
USP7-Based Deubiquitinase-Targeting Chimeras Stabilize AMPK.
Liu J, Hu X, Luo K, Xiong Y, Chen L, Wang Z, Inuzuka H, Qian C, Yu X, Xie L, Muneer A, Zhang D, Paulo JA, Chen X, Jin J, Wei W. Liu J, et al. Among authors: paulo ja. J Am Chem Soc. 2024 Apr 10. doi: 10.1021/jacs.4c02373. Online ahead of print. J Am Chem Soc. 2024. PMID: 38597345
Targetable leukaemia dependency on noncanonical PI3Kγ signalling.
Luo Q, Raulston EG, Prado MA, Wu X, Gritsman K, Whalen KS, Yan K, Booth CAG, Xu R, van Galen P, Doench JG, Shimony S, Long HW, Neuberg DS, Paulo JA, Lane AA. Luo Q, et al. Among authors: paulo ja. Nature. 2024 May 8. doi: 10.1038/s41586-024-07410-3. Online ahead of print. Nature. 2024. PMID: 38720074
Recharacterization of RSL3 reveals that the selenoproteome is a druggable target in colorectal cancer.
DeAngelo SL, Dziechciarz S, Solanki S, Shin M, Zhao L, Balia A, El-Derany MO, Das NK, Castillo C, Bell HN, Paulo JA, Zhang Y, Rossiter NJ, McCulla EC, He J, Talukder I, Schafer ZT, Neamati N, Mancias JD, Koutmos M, Shah YM. DeAngelo SL, et al. Among authors: paulo ja. bioRxiv [Preprint]. 2024 Apr 1:2024.03.29.587381. doi: 10.1101/2024.03.29.587381. bioRxiv. 2024. PMID: 38617233 Free PMC article. Preprint.
297 results