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Cancer-associated fibroblasts produce matrix-bound vesicles that influence endothelial cell function.
Santi A, Kay EJ, Neilson LJ, McGarry L, Lilla S, Mullin M, Paul NR, Fercoq F, Koulouras G, Rodriguez Blanco G, Athineos D, Mason S, Hughes M, Thomson G, Kieffer Y, Nixon C, Blyth K, Mechta-Grigoriou F, Carlin LM, Zanivan S. Santi A, et al. Among authors: paul nr. Sci Signal. 2024 Mar 12;17(827):eade0580. doi: 10.1126/scisignal.ade0580. Epub 2024 Mar 12. Sci Signal. 2024. PMID: 38470957
CYRI/ Fam49 Proteins Represent a New Class of Rac1 Interactors.
Whitelaw JA, Lilla S, Paul NR, Fort L, Zanivan S, Machesky LM. Whitelaw JA, et al. Among authors: paul nr. Commun Integr Biol. 2019 Jul 23;12(1):112-118. doi: 10.1080/19420889.2019.1643665. eCollection 2019. Commun Integr Biol. 2019. PMID: 31413787 Free PMC article.
Increased apoptotic sensitivity of glioblastoma enables therapeutic targeting by BH3-mimetics.
Koessinger AL, Cloix C, Koessinger D, Heiland DH, Bock FJ, Strathdee K, Kinch K, Martínez-Escardó L, Paul NR, Nixon C, Malviya G, Jackson MR, Campbell KJ, Stevenson K, Davis S, Elmasry Y, Ahmed A, O'Prey J, Ichim G, Schnell O, Stewart W, Blyth K, Ryan KM, Chalmers AJ, Norman JC, Tait SWG. Koessinger AL, et al. Among authors: paul nr. Cell Death Differ. 2022 Oct;29(10):2089-2104. doi: 10.1038/s41418-022-01001-3. Epub 2022 Apr 26. Cell Death Differ. 2022. PMID: 35473984 Free PMC article.
Structure-based design, synthesis and biological evaluation of a novel series of isoquinolone and pyrazolo[4,3-c]pyridine inhibitors of fascin 1 as potential anti-metastatic agents.
Francis S, Croft D, Schüttelkopf AW, Parry C, Pugliese A, Cameron K, Claydon S, Drysdale M, Gardner C, Gohlke A, Goodwin G, Gray CH, Konczal J, McDonald L, Mezna M, Pannifer A, Paul NR, Machesky L, McKinnon H, Bower J. Francis S, et al. Among authors: paul nr. Bioorg Med Chem Lett. 2019 Apr 15;29(8):1023-1029. doi: 10.1016/j.bmcl.2019.01.035. Epub 2019 Jan 30. Bioorg Med Chem Lett. 2019. PMID: 30773430 Free PMC article.
Isolation of integrin-based adhesion complexes.
Jones MC, Humphries JD, Byron A, Millon-Frémillon A, Robertson J, Paul NR, Ng DHJ, Askari JA, Humphries MJ. Jones MC, et al. Among authors: paul nr. Curr Protoc Cell Biol. 2015 Mar 2;66:9.8.1-9.8.15. doi: 10.1002/0471143030.cb0908s66. Curr Protoc Cell Biol. 2015. PMID: 25727331 Free PMC article.
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