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A synthetic lipopeptide targeting top-priority multidrug-resistant Gram-negative pathogens.
Roberts KD, Zhu Y, Azad MAK, Han ML, Wang J, Wang L, Yu HH, Horne AS, Pinson JA, Rudd D, Voelcker NH, Patil NA, Zhao J, Jiang X, Lu J, Chen K, Lomovskaya O, Hecker SJ, Thompson PE, Nation RL, Dudley MN, Griffith DC, Velkov T, Li J. Roberts KD, et al. Among authors: patil na. Nat Commun. 2022 Mar 25;13(1):1625. doi: 10.1038/s41467-022-29234-3. Nat Commun. 2022. PMID: 35338128 Free PMC article.
Polymyxins Bind to the Cell Surface of Unculturable Acinetobacter baumannii and Cause Unique Dependent Resistance.
Zhu Y, Lu J, Han ML, Jiang X, Azad MAK, Patil NA, Lin YW, Zhao J, Hu Y, Yu HH, Chen K, Boyce JD, Dunstan RA, Lithgow T, Barlow CK, Li W, Schneider-Futschik EK, Wang J, Gong B, Sommer B, Creek DJ, Fu J, Wang L, Schreiber F, Velkov T, Li J. Zhu Y, et al. Among authors: patil na. Adv Sci (Weinh). 2020 Jun 8;7(15):2000704. doi: 10.1002/advs.202000704. eCollection 2020 Aug. Adv Sci (Weinh). 2020. PMID: 32775156 Free PMC article.
Molecular dynamics simulations informed by membrane lipidomics reveal the structure-interaction relationship of polymyxins with the lipid A-based outer membrane of Acinetobacter baumannii.
Jiang X, Yang K, Yuan B, Han M, Zhu Y, Roberts KD, Patil NA, Li J, Gong B, Hancock REW, Velkov T, Schreiber F, Wang L, Li J. Jiang X, et al. Among authors: patil na. J Antimicrob Chemother. 2020 Dec 1;75(12):3534-3543. doi: 10.1093/jac/dkaa376. J Antimicrob Chemother. 2020. PMID: 32911540 Free PMC article.
A novel chemical biology and computational approach to expedite the discovery of new-generation polymyxins against life-threatening Acinetobacter baumannii.
Jiang X, Patil NA, Azad MAK, Wickremasinghe H, Yu H, Zhao J, Zhang X, Li M, Gong B, Wan L, Ma W, Thompson PE, Yang K, Yuan B, Schreiber F, Wang L, Velkov T, Roberts KD, Li J. Jiang X, et al. Among authors: patil na. Chem Sci. 2021 Aug 19;12(36):12211-12220. doi: 10.1039/d1sc03460j. eCollection 2021 Sep 22. Chem Sci. 2021. PMID: 34667587 Free PMC article.
Structure-Interaction Relationship of Polymyxins with Lung Surfactant.
Jiang X, Patil NA, Xu Y, Wickremasinghe H, Zhou QT, Zhou F, Thompson PE, Wang L, Xiao M, Roberts KD, Velkov T, Li J. Jiang X, et al. Among authors: patil na. J Med Chem. 2023 Dec 14;66(23):16109-16119. doi: 10.1021/acs.jmedchem.3c01497. Epub 2023 Nov 29. J Med Chem. 2023. PMID: 38019899
43 results